Dynamics of picosecond laser ablation for surgical treatment of colorectal cancer.
Dynamics of picosecond laser ablation for surgical treatment of colorectal cancer.
复制标题
皮秒激光消融的动力学，用于进行结直肠癌的手术治疗。
DOI：
10.1038/s41598-020-73349-w
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发表时间：
2020-11-20
影响因子：
4.6
通讯作者：
Shephard JD
中科院分区：
文献类型：
--
作者：
Beck RJ;Bitharas I;Hand DP;Maisey T;Moore AJ;Shires M;Thomson RR;West NP;Jayne DG;Shephard JD
治疗结直肠肿瘤的腔内手术通常使用电灼工具进行，这意味着精度有限，并且存在因对邻近健康组织造成附带热损伤而造成伤害的风险。作为一种潜在的替代方案，我们展示了通过皮秒激光脉冲成功进行的结肠上皮激光消融。在离体结肠组织中进行的激光消融研究产生的空腔厚度与早期结直肠癌相当。相应的组织学切片对周围组织仅表现出最小的附带损伤，并且可以通过脉冲能量精确控制消融的深度。高速成像首次用于在临床相关模型中可视化皮秒激光消融癌组织。该信息与组织病理学和光学表面轮廓测量法相关，揭示了激光组织相互作用的动态性质以及脉冲的时间或空间分离的需要，以实现组织去除的最佳功效。总体而言，与传统手术相比，应用皮秒激光脉冲消融肠腔内病变的精度显着提高，并减少了对邻近组织的热损伤，因此将使癌症的手术治疗更加精确。
Endoluminal surgery for the treatment of colorectal neoplasia is typically carried out using electrocautery tools which imply limited precision and the risk of harm through collateral thermal damage to the adjacent healthy tissue. As a potential alternative, we present the successful colonic epithelial laser ablation by means of picosecond laser pulses. Laser ablation studies performed in ex-vivo colon tissue result in cavities with comparable thickness to early stage colorectal cancers. The corresponding histology sections exhibit only minimal collateral damage to the surrounding tissue and the depth of the ablation can be controlled precisely by means of the pulse energy. High-speed imaging has been used for the first time to visualize picosecond laser ablation of cancerous tissue in a clinically relevant model. This information was correlated with histopathology and optical surface profilometry revealing the dynamic nature of the laser tissue interaction and the need for temporal or spatial separation of pulses for optimum efficacy with regards to tissue removal. Overall, the application of picosecond laser pulses to ablate endoluminal bowel lesions demonstrates significantly improved precision and reduced thermal damage to the adjacent tissue in comparison to conventional procedures and hence will enable more precise surgical treatment of cancers.
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影响因子：
3.7
作者：
Linz, Norbert;Freidank, Sebastian;Vogel, Alfred
通讯作者：
Vogel, Alfred
飞秒激光用于牙釉质和牙本质腔预备：消融效率相关因素
影响因子：
4.6
作者：
Chen H;Li H;Sun Y;Wang Y;Lü P
通讯作者：
Lü P
DOI：
10.1073/pnas.0434905100
发表时间：
2003-03-04
影响因子：
11.1
作者：
Pitari, GM;Zingman, LV;Waldman, SA
通讯作者：
Waldman, SA
影响因子：
5
作者：
Zhao, Wanqin;Wang, Lingzhi
通讯作者：
Wang, Lingzhi
影响因子：
9.4
作者：
Bidare, P.;Bitharas, I.;Moore, A. J.
通讯作者：
Moore, A. J.