Sodium bicarbonate cotransporter NBCn1/Slc4a7 affects locomotor activity and hearing in mice.

Sodium bicarbonate cotransporter NBCn1/Slc4a7 affects locomotor activity and hearing in mice.
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DOI:
10.1016/j.bbr.2020.113065
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发表时间:
2021-03-05
影响因子:
2.7
通讯作者:
Boedtkjer, Ebbe
Boedtkjer, Ebbe
中科院分区:
心理学3区
文献类型:
--
作者:
Choi, Inyeong;Beedholm, Kristian;Dam, Vibeke S.;Bae, Seong-Ho;Noble, Donald J.;Garraway, Sandra M.;Aalkjaer, Christian;Boedtkjer, Ebbe

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尽管在中枢神经系统中广泛的表达模式,碳酸氢钠协同转运蛋白NBCn 1/Slc 4a 7的作用还没有被调查的自发活动,情绪和认知。在这里,我们讨论了NBCn 1基因敲除的行为后果,并评估了据报道在早期NBCn 1基因敲除小鼠中受损的听力和视力,这可能有助于行为变化。在一个圆形的开放领域,基因敲除小鼠比野生型同窝小鼠行进更短的距离,特别是在室的周边。基因敲除小鼠在一个类似笼子的开放场地中的总距离也较短。饲养和梳理行为减少。敲除小鼠和对照小鼠在高架十字迷宫测试中显示出相似的时间花费和张开臂和闭合臂的数量,表明焦虑的变化可以忽略不计。在Morris水迷宫测试中,两组小鼠在训练试验的可比时间内学习了逃逸平台的位置,并在探针试验中显示出相似的平台识别。敲除小鼠在视动性鼓中保持正常的视觉反应,并产生响应于光刺激的诱发电位。然而,这些小鼠未能产生听觉诱发电位。qPCR揭示了在敲除小鼠视网膜中交替转录的NBCn 1变体的稳健表达。这些结果表明,NBCn 1缺失通过影响小鼠的探索行为或情绪导致小鼠运动活动减少。这种缺失也会导致听力损失,但其对视力的影响在不同的基因敲除小鼠品系之间存在差异。
Despite a widespread expression pattern in the central nervous system, the role of the sodium bicarbonate cotransporter NBCn1/Slc4a7 has not been investigated for locomotor activity, emotion and cognition. Here, we addressed the behavioral consequences of NBCn1 knockout and evaluated hearing and vision that are reportedly impaired in an earlier line of NBCn1 knockout mice and may contribute to behavioral changes. In a circular open field, the knockout mice traveled a shorter distance, especially in the periphery of the chamber, than wildtype littermates. The knockout mice also traveled a shorter total distance in a home cage-like open field. Rearing and grooming behaviors were reduced. The knockout and control mice displayed similar time spent and number of open and closed arms in the elevated plus maze test, indicating negligible change in anxiety. In the Morris water maze test, both groups of mice learned the location of an escape platform within comparable time on the training trials and showed similar platform identification on the probe trial. The knockout mice maintained normal visual responses in the optokinetic drum and produced evoked potentials in response to light stimuli. However, these mice failed to produce auditory evoked potentials. qPCR revealed a robust expression of an alternatively transcribed NBCn1 variant in the knockout mouse retina. These results indicate that NBCn1 deletion leads to reduced locomotor activity in mice by affecting their exploratory behaviors or emotionality. The deletion also causes hearing loss, but its effect on vision varies between different lines of knockout mice.
DOI: 10.1038/nature10405
发表时间: 2011-09-11
期刊: NATURE
影响因子: 64.8
作者:
Ehret, Georg B.;Munroe, Patricia B.;Rice, Kenneth M.;Bochud, Murielle;Johnson, Andrew D.;Chasman, Daniel I.;Smith, Albert V.;Tobin, Martin D.;Verwoert, Germaine C.;Hwang, Shih-Jen;Pihur, Vasyl;Vollenweider, Peter;O'Reilly, Paul F.;Amin, Najaf;Bragg-Gresham, Jennifer L.;Teumer, Alexander;Glazer, Nicole L.;Launer, Lenore;Zhao, Jing Hua;Aulchenko, Yurii;Heath, Simon;Sober, Siim;Parsa, Afshin;Luan, Jian'an;Arora, Pankaj;Dehghan, Abbas;Zhang, Feng;Lucas, Gavin;Hicks, Andrew A.;Jackson, Anne U.;Peden, John F.;Tanaka, Toshiko;Wild, Sarah H.;Rudan, Igor;Igl, Wilmar;Milaneschi, Yuri;Parker, Alex N.;Fava, Cristiano;Chambers, John C.;Fox, Ervin R.;Kumari, Meena;Go, Min Jin;van der Harst, Pim;Kao, Wen Hong Linda;Sjogren, Marketa;Vinay, D. G.;Alexander, Myriam;Tabara, Yasuharu;Shaw-Hawkins, Sue;Whincup, Peter H.;Liu, Yongmei;Shi, Gang;Kuusisto, Johanna;Tayo, Bamidele;Seielstad, Mark;Sim, Xueling;Khanh-Dung Hoang Nguyen;Lehtimaki, Terho;Matullo, Giuseppe;Wu, Ying;Gaunt, Tom R.;Onland-Moret, N. 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通讯作者: Johnson, Toby
DOI: 10.1016/j.visres.2004.12.015
发表时间: 2005-05-01
期刊: VISION RESEARCH
影响因子: 1.8
作者:
Abdejalil, J;Hamid, M;Serge, P
通讯作者: Serge, P
DOI: 10.1016/s0378-5955(01)00298-2
发表时间: 2001-07-01
期刊: HEARING RESEARCH
影响因子: 2.8
作者:
Heffner, RS;Koay, G;Heffner, HE
通讯作者: Heffner, HE
DOI: 10.1038/35014615
发表时间: 2000-06-01
期刊: NATURE
影响因子: 64.8
作者:
Choi, I;Aalkjaer, C;Boron, WF
通讯作者: Boron, WF
DOI: 10.1113/jphysiol.2011.226506
发表时间: 2012-07-01
影响因子: 5.5
作者:
Chen, Mingmin;Praetorius, Jeppe;Seidler, Ursula
通讯作者: Seidler, Ursula