The effects of metal implants on inflammatory and healing processes

The effects of metal implants on inflammatory and healing processes
复制标题

金属植入物对炎症和愈合过程的影响

DOI:
10.3139/146.101508
复制
发表时间:
2007
影响因子:
0.8
通讯作者:
C. Kirkpatrick
C. Kirkpatrick
中科院分区:
材料科学4区
文献类型:
--
作者:
R. Tsaryk;K. Peters;R. Unger;D. Scharnweber;C. Kirkpatrick

文献摘要

参考文献

被引文献

相似文献

摘要 金属植入物以其优越的机械性能而闻名。然而,主要由于无菌性松动而导致种植体失败的情况确实发生过。颗粒磨损碎片和腐蚀产物(例如金属离子和活性氧)的形成被认为是导致金属植入物失效的关键因素。这些金属降解和腐蚀产物可诱发由中性粒细胞、巨噬细胞和内皮细胞介导的炎症反应。此外,这些降解产物可能会影响血管形成,这是植入后伤口愈合的核心过程之一。此类事件可能导致植入物无菌性松动,最终导致需要进行修复手术。
Abstract Metal implants are known for their superior mechanical properties. However, cases of implant failure mainly due to aseptic loosening do occur. The formation of particulate wear debris and corrosion products, such as metal ions and reactive oxygen species, are considered to be crucial factors leading to the failure of metal implants. These metal degradation and corrosion products can induce inflammatory responses, mediated among others by neutrophils, macrophages and endothelial cells. Furthermore, these degradation products may affect blood vessel formation, one of the central processes in wound healing after implantation. Such events can lead to the aseptic loosening of implants culminating in the necessity for revision surgery.
DOI: 10.1161/01.res.81.1.24
发表时间: 1997-07-01
影响因子: 20.1
作者:
Ruef, J;Hu, ZY;Patterson, C
通讯作者: Patterson, C
DOI: 10.2106/00004623-199173100-00005
发表时间: 1991-12-01
影响因子: 5.3
作者:
JACOBS, JJ;SKIPOR, AK;GALANTE, JO
通讯作者: GALANTE, JO
DOI: 10.1097/01.ju.0000058406.16931.93
发表时间: 2003-06-01
期刊: JOURNAL OF UROLOGY
影响因子: 6.6
作者:
Buttyan, R;Chichester, P;Levin, RM
通讯作者: Levin, RM