Therapeutic role and ligands of medium- to long-chain Fatty Acid receptors.
Therapeutic role and ligands of medium- to long-chain Fatty Acid receptors.
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DOI：
10.3389/fendo.2014.00083
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发表时间：
2014
影响因子：
5.2
通讯作者：
Hirasawa A
中科院分区：
文献类型：
--
作者：
Hara T;Ichimura A;Hirasawa A
中链和长链游离脂肪酸 (FFA) 是全身和生物代谢物和成分的能量来源。近几十年来，一些研究小组报道，中长链FFA的生物学功能是通过G蛋白偶联受体（称为游离脂肪酸受体（FFAR））发挥的。作为中长链FFA激活的FFAR，FFA1和FFA4据报道在全身广泛表达并调节各种生理过程。胰腺 β 细胞中表达的 FFA1 已被证明参与胰岛素分泌。 FFA4 在肠道、脂肪细胞和巨噬细胞中表达，已被证明分别参与肠促胰岛素分泌、分化和抗炎作用。这些生理功能已集中于代谢紊乱的治疗。此外，据报道这些受体也在其他几种组织中表达，例如 FFA1 的肠道、FFA4 的舌头和胃。最近的功能研究表明它们还有助于能量稳态。此外，FFA1和FFA4的合成化合物的数量强烈促进了受体的生理学特征及其自身的治疗效用。在本文中，我们将讨论这些受体及其配体的治疗潜力的最新进展。
Medium- and long-chain free fatty acids (FFAs) are energy source for whole body and biological metabolites and components. In these decades, some research groups have reported that the biological functions of medium- to long-chain FFAs are exerted through G-protein coupled receptor designated free fatty acid receptor (FFAR). As the medium- to long-chain FFAs-activated FFARs, FFA1 and FFA4 are reported to be expressed widely in whole body and regulate various physiological processes. FFA1 expressed in pancreatic β-cells has been shown to be involved in insulin secretion. FFA4 expressed in intestine, adipocytes, and macrophages has been shown to be involved in incretin secretion, differentiation, and anti-inflammatory effect, respectively. These physiological functions have been focused on the treatment of metabolic disorders. In addition, these receptors have been also reported to be expressed in several other tissues such as intestine for FFA1, and tongue and stomach for FFA4. The recent functional studies indicated that they also contributed to energy homeostasis. Further, the number of synthetic compounds of FFA1 and FFA4 strongly promoted the physiological characterization of the receptors and their own therapeutic utility. In this article, we will discuss the recent progress regarding the therapeutic potential of these receptors and its ligands.
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影响因子：
4.1
作者：
Abaraviciene, Sandra Meidute;Muhammed, Sarheed J.;Salehi, Albert
通讯作者：
Salehi, Albert
影响因子：
8.2
作者：
Ferdaoussi, M.;Bergeron, V.;Poitout, V.
通讯作者：
Poitout, V.
影响因子：
4.8
作者：
Brown, AJ;Goldsworthy, SM;Dowell, SJ
通讯作者：
Dowell, SJ
DOI：
10.1016/s0952-3278(97)90500-7
发表时间：
1997-07-01
影响因子：
3
作者：
Nunez, EA
通讯作者：
Nunez, EA
影响因子：
7.7
作者：
Edfalk S;Steneberg P;Edlund H
通讯作者：
Edlund H