Hidden Markov Models and their Applications in Biological Sequence Analysis.
Hidden Markov Models and their Applications in Biological Sequence Analysis.
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DOI：
10.2174/138920209789177575
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发表时间：
2009-09
期刊：
影响因子：
2.6
通讯作者：
Yoon BJ
中科院分区：
文献类型：
--
作者：
Yoon BJ
Hidden Markov models (HMMs) have been extensively used in biological sequence analysis. In this paper, we give a tutorial review of HMMs and their applications in a variety of problems in molecular biology. We especially focus on three types of HMMs: the profile-HMMs, pair-HMMs, and context-sensitive HMMs. We show how these HMMs can be used to solve various sequence analysis problems, such as pairwise and multiple sequence alignments, gene annotation, classification, similarity search, and many others.
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