Failure of manganese to protect from Shiga toxin.
Failure of manganese to protect from Shiga toxin.
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DOI：
10.1371/journal.pone.0069823
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Weiss AA
中科院分区：
文献类型：
--
作者：
Gaston MA;Pellino CA;Weiss AA
Shiga toxin (Stx), the main virulence factor of Shiga toxin producing Escherichia coli, is a major public health threat, causing hemorrhagic colitis and hemolytic uremic syndrome. Currently, there are no approved therapeutics for these infections; however manganese has been reported to provide protection from the Stx1 variant isolated from Shigella dysenteriae (Stx1-S) both in vitro and in vivo. We investigated the efficacy of manganese protection from Stx1-S and the more potent Stx2a isoform, using experimental systems well-established for studying Stx: in vitro responses of Vero monkey kidney cells, and in vivo toxicity to CD-1 outbred mice. Manganese treatment at the reported therapeutic concentration was toxic to Vero cells in culture and to CD-1 mice. At lower manganese concentrations that were better tolerated, we observed no protection from Stx1-S or Stx2a toxicity. The ability of manganese to prevent the effects of Stx may be particular to certain cell lines, mouse strains, or may only be manifested at high, potentially toxic manganese concentrations.
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影响因子：
64.5
作者：
BORGSTAHL, GEO;PARGE, HE;TAINER, JA
通讯作者：
TAINER, JA
影响因子：
9.4
作者：
Boerlin, P;McEwen, SA;Gyles, CL
通讯作者：
Gyles, CL
影响因子：
3.1
作者：
TESH, VL;BURRIS, JA;SAMUEL, JE
通讯作者：
SAMUEL, JE
DOI：
10.1126/science.1215930
发表时间：
2012-01-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Mukhopadhyay S;Linstedt AD
通讯作者：
Linstedt AD
影响因子：
3.5
作者：
LAUWERYS, R;ROELS, H;DECOOMAN, S
通讯作者：
DECOOMAN, S