Evaluation of Serum CEA, CA19-9, CA72-4, CA125 and Ferritin as Diagnostic Markers and Factors of Clinical Parameters for Colorectal Cancer.
Evaluation of Serum CEA, CA19-9, CA72-4, CA125 and Ferritin as Diagnostic Markers and Factors of Clinical Parameters for Colorectal Cancer.
复制标题
DOI：
10.1038/s41598-018-21048-y
复制
发表时间：
2018-02-09
影响因子：
4.6
通讯作者：
Huo X
中科院分区：
文献类型：
--
作者：
Gao Y;Wang J;Zhou Y;Sheng S;Qian SY;Huo X
基于血液的蛋白质生物标志物最近被证明是结直肠癌的简单诊断方式，但它们与临床病理特征的关系在很大程度上是未知的。在这项研究中，我们不仅检验了单一/多个血清标志物诊断的敏感性和可靠性，而且还评估了它们与279例结直肠癌患者病理参数的联系。我们的研究表明，糖蛋白癌胚抗原（CEA）在CEA >癌抗原72-4 (CA72-4) >癌抗原19- 99 (CA19-9) >铁蛋白>癌抗原125 （CA125）的单标记中敏感性最高，而最敏感的组合标记有2 ~ 5个：CEA + CA72-4；cea + ca72-4 + ca125；cea + ca19-9 + ca72-4 + ca125；CEA + CA19-9 + CA72-4 + CA125 +铁蛋白。我们还发现，术前血清CEA、CA19-9或CA72-4阳性的患者更容易发生淋巴结侵犯，CA125阳性的患者容易发生血管侵犯，CEA或CA125阳性的患者与周围神经侵犯相关。此外，CA19-9、CA72-4、CA125阳性与低分化肿瘤相关，而CEA、CA19-9、CA72-4、CA125阳性与病理肿瘤淋巴结转移分期呈正相关。综上所述，联合血清标志物不仅可以用于大肠癌的诊断，还可以评价肿瘤状态，指导治疗、评价疗效和患者预后。
Blood-based protein biomarkers have recently shown as simpler diagnostic modalities for colorectal cancer, while their association with clinical pathological characteristics is largely unknown. In this study, we not only examined the sensitivity and reliability of single/multiple serum markers for diagnosis, but also assessed their connection with pathological parameters from a total of 279 colorectal cancer patients. Our study shown that glycoprotein carcinoembryonic antigen (CEA) owns the highest sensitivity among single marker in the order of CEA > cancer antigen 72-4 (CA72-4) > cancer antigen 19-9 9 (CA19-9) > ferritin > cancer antigen 125 (CA125), while the most sensitive combined-markers for two to five were: CEA + CA72-4; CEA + CA72-4 + CA125; CEA + CA19-9 + CA72-4 + CA125; and CEA + CA19-9 + CA72-4 + CA125 + ferritin, respectively. We also demonstrated that patients who had positive preoperative serum CEA, CA19-9, or CA72-4 were more likely with lymph node invasion, positive CA125 were prone to have vascular invasion, and positive CEA or CA125 were correlated with perineural invasion. In addition, positive CA19-9, CA72-4, or CA125 was associated with poorly differentiated tumor, while CEA, CA19-9, CA72-4, CA125 levels were positively correlated with pathological tumor-node-metastasis stages. We here conclude that combined serum markers can be used to not only diagnose colorectal cancer, but also appraise the tumor status for guiding treatment, evaluation of curative effect, and prognosis of patients.
登录
查看更多内容
影响因子：
29.4
作者：
Kahi, Charles J.;Boland, C. Richard;Rex, Douglas K.
通讯作者：
Rex, Douglas K.
影响因子：
4
作者：
Keller, G;Vogelsang, H;Höfler, H
通讯作者：
Höfler, H
影响因子：
10.3
作者：
MUGHAL, S;FILIPE, MI
通讯作者：
FILIPE, MI
影响因子：
5.5
作者：
Bagaria B;Sood S;Sharma R;Lalwani S
通讯作者：
Lalwani S
DOI：
10.1093/jnci/92.7.557
发表时间：
2000-04-05
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Loeve, F;Brown, ML;Habbema, JDF
通讯作者：
Habbema, JDF