Effect of initial cell-seeding density on postoperative cell number and dispersion.
Effect of initial cell-seeding density on postoperative cell number and dispersion.
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初始细胞接种密度对术后细胞数量和分散度的影响。
DOI：
10.1089/ten.2005.11.1898
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Boivin,Gregory
中科院分区：
文献类型：
--
作者：
Shearn,Jason;Hellmann,Lauren;Boivin,Gregory
每年，超过100，000个肌腱由于创伤性损伤、慢性疾病或用于韧带重建的切除而受损。根据损伤的严重程度，这些疾病的治疗取得了不同的成功。1-4在大多数情况下，肌腱病变的干预已被证明可产生良好或极佳的结局。1、4、5对于股四头肌腱病的修复，修复肢体的强度等同于对侧肢体的强度。6然而，使用超声或磁共振成像（MRI），修复肌腱的外观异常。当肌腱断裂修复时，肌腱通常不能恢复到损伤前的强度或大小。2，3，8在随访检查中，修复的肌腱明显大于对侧肌腱，8，9，串联肌肉的强度受损高达16.6%。2除了这些损伤，当肌腱被用作交叉韧带重建的移植物时，会产生大的髌腱缺损。髌腱中产生的差距未修复。短期随访发现，剩余髌腱支柱之间的面积减小，但2 mm的间隙存在长达27个月。肌腱不完全愈合会导致慢性疼痛、活动受限和组织退化。一些研究关注于提高肌腱修复的成功率。这些研究中的许多使用了功能性组织工程方法，该方法确定了组织的机械和结构要求，并将其用作修复设计的模型。11-13与自然修复相比，这种方法显著改善了组织质量，但修复组织仍低于正常组织。14-16通常，修复的组分是细胞与支架或递送载体的组合。例如，间充质干细胞（MSC）、纤维蛋白胶和编织的聚丙交酯-共-gly-
ANNUALLY, MORE THAN 100,000 TENDONS are com-promised as a result of traumatic injury, chronic disorder, or removal for use in ligament reconstruction. Treatment of these disorders has had varying success depending on the severity of the injury. 1–4 Intervention for tendinopathies has been shown to produce good or excellent outcome in a majority of cases. 1, 4, 5 For repair of quadriceps tendinopathy, the strength in the repaired limb is equivalent to that of the contralateral limb. 6 However, the appearance of the repaired tendon, using ultrasound or magnetic resonance imaging (MRI), is abnormal. 7 When tendinous ruptures are repaired, the tendon is not typically restored to preinjury strength or size. 2, 3, 8 The repaired tendons on follow-up examination are significantly larger than the contralateral tendon, 8, 9 and the strength of the in-series muscle is compromised by as much as 16.6%. 2 In addition to these injuries, large patellar tendon defects are created when the tendon is used as the graft for cruciate ligament reconstruction. The gap created in the patellar tendon is not repaired. Short-term follow-up found that the area between the remaining patellar tendon struts decreased, but a 2-mm gap was present for as long as 27 months. 10 Incomplete tendon healing can lead to chronic pain, activity limitations, and tissue degeneration.Several studies have focused on improving the success of tendon repair. Many of these studies used a functional tissue-engineering approach, which determines mechanical and structural requirements for a tissue and uses them as a model for the repair design. 11–13 This approach has resulted in a significant improvement in tissue quality compared with natural repair, but the repair tissue is still inferior to normal. 14–16 Typically the components of the repairs are a combination of cells with a scaffold or delivery vehicle. For example, mesenchymal stem cells (MSCs), fibrin glue, and a knitted poly-lactide-co-gly-
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开放式和关节镜下髌腱切断术治疗慢性髌腱病
DOI：
10.1177/03635465000280020801
发表时间：
2000
期刊：
The American Journal of Sports Medicine
影响因子：
--
作者：
B. D. Coleman;K. Khan;K. Khan;Z. S. Kiss;J. Bartlett;D. Young;J. Wark
通讯作者：
J. Wark
影响因子：
4.8
作者：
Marder, RA;Timmerman, LA
通讯作者：
Timmerman, LA
大鼠尾腱生长过程中成纤维细胞之间的空间关系
影响因子：
3.6
作者：
C. Squier;Craig Magnes
通讯作者：
Craig Magnes
影响因子：
2.5
作者：
J. Leppilahti;P. Siira;H. Vanharanta;S. Orava
通讯作者：
S. Orava
使用新评分方法进行跟腱断裂修复的结果和预后因素
影响因子：
4.2
作者：
J. Leppilahti;Kari Forsman;J. Puranen;S. Orava
通讯作者：
S. Orava