Biomarkers for early diagnosis of malignant mesothelioma: Do we need another moonshot?
Biomarkers for early diagnosis of malignant mesothelioma: Do we need another moonshot?
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DOI：
10.18632/oncotarget.17910
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发表时间：
2017-08-08
期刊：
影响因子：
--
通讯作者：
Vermaelen KY
中科院分区：
文献类型：
--
作者：
Lagniau S;Lamote K;van Meerbeeck JP;Vermaelen KY
恶性胸膜间皮瘤（MPM）的早期诊断对临床医生来说是一个挑战。这种疾病通常在晚期被发现，这使得无法进行治疗。我们认为，只有新的和非侵入性的生物标志物允许早期检测将导致更好的患者管理和结果。已经做出了许多努力来寻找血液和胸腔积液中合适的生物标志物，但尚未产生有效且可重复的诊断标志物。在这篇综述中，我们将突出血液和液体为基础的生物标志物的优点和缺点，并强调呼吸分析作为MPM的非侵入性筛查工具的潜力。这种方法似乎非常有前途的早期检测各种恶性肿瘤，因为呼出的气体包含有价值的信息细胞和组织的代谢。专注于MPM中呼吸生物标志物的研究尚处于早期阶段，但已进行的少数研究显示出有希望的结果。我们认为，应该进一步探索基于呼吸生物标志物的方法，以改善石棉暴露个体的随访和管理。
Early diagnosis of malignant pleural mesothelioma (MPM) is a challenge for clinicians. The disease is usually detected in an advanced stage which precludes curative treatment. We assume that only new and non-invasive biomarkers allowing earlier detection will result in better patient management and outcome. Many efforts have already been made to find suitable biomarkers in blood and pleural effusions, but have not yet resulted in a valid and reproducible diagnostic one. In this review, we will highlight the strengths and shortcomings of blood and fluid based biomarkers and highlight the potential of breath analysis as a non-invasive screening tool for MPM. This method seems very promising in the early detection of diverse malignancies, because exhaled breath contains valuable information on cell and tissue metabolism. Research that focuses on breath biomarkers in MPM is in its early days, but the few studies that have been performed show promising results. We believe a breathomics-based biomarker approach should be further explored to improve the follow-up and management of asbestos exposed individuals.
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