The duck genome and transcriptome provide insight into an avian influenza virus reservoir species.
The duck genome and transcriptome provide insight into an avian influenza virus reservoir species.
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DOI：
10.1038/ng.2657
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发表时间：
2013-07
期刊：
影响因子：
30.8
通讯作者：
Li, Ning
中科院分区：
文献类型：
--
作者：
Huang, Yinhua;Li, Yingrui;Burt, David W.;Chen, Hualan;Zhang, Yong;Qian, Wubin;Kim, Heebal;Gan, Shangquan;Zhao, Yiqiang;Li, Jianwen;Yi, Kang;Feng, Huapeng;Zhu, Pengyang;Li, Bo;Liu, Qiuyue;Fairley, Suan;Magor, Katharine E.;Du, Zhenlin;Hu, Xiaoxiang;Goodman, Laurie;Tafer, Hakim;Vignal, Alain;Lee, Taeheon;Kim, Kyu-Won;Sheng, Zheya;An, Yang;Searle, Steve;Herrero, Javier;Groenen, Martien A. M.;Crooijmans, Richard P. M. A.;Faraut, Thomas;Cai, Qingle;Webster, Robert G.;Aldridge, Jerry R.;Warren, Wesley C.;Bartschat, Sebastian;Kehr, Stephanie;Marz, Manja;Stadler, Peter F.;Smith, Jacqueline;Kraus, Robert H. S.;Zhao, Yaofeng;Ren, Liming;Fei, Jing;Morisson, Mireille;Kaiser, Pete;Griffin, Darren K.;Rao, Man;Pitel, Frederique;Wang, Jun;Li, Ning
鸭子是甲型流感病毒的主要自然宿主之一。我们给出了鸭子的基因组序列，并进行了深入的转录组分析，以研究免疫相关基因。我们的数据表明，鸭子拥有一个收缩免疫基因库，就像鸡和斑马雀一样，这个基因库是通过特定血统的复制而形成的。我们使用对照鸭和感染高致病性(A/鸭子/湖北/49/05)或弱致病性(A/Goose/湖北/65/05)H5N1病毒的鸭子的肺转录来识别对甲型流感病毒有反应的基因。此外，我们还展示了如何通过β-防御素和类丁咯菲林酶系的多样化来优化鸭子对流感感染的防御机制。这些分析与基因组和转录组数据相结合，为描述宿主和流感病毒之间的相互作用提供了资源。
The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck’s defense mechanisms against influenza infection have been optimized through the diversification of its β-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.
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影响因子：
4.5
作者：
Hahn MW;Han MV;Han SG
通讯作者：
Han SG
Narcisse：保守同时的镜像。
影响因子：
14.9
作者：
Courcelle E;Beausse Y;Letort S;Stahl O;Fremez R;Ngom-Bru C;Gouzy J;Faraut T
通讯作者：
Faraut T
DOI：
10.1073/pnas.1010647108
发表时间：
2011-03-15
影响因子：
11.1
作者：
Bas, Anna;Swamy, Mahima;Hayday, Adrian C.
通讯作者：
Hayday, Adrian C.
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影响因子：
14.9
作者：
Li, Heng;Coghlan, Avril;Ruan, Jue;Coin, Lachlan James;Heriche, Jean-Karim;Osmotherly, Lara;Li, Ruiqiang;Liu, Tao;Zhang, Zhang;Bolund, Lars;Wong, Gane Ka-Shu;Zheng, Weimou;Dehal, Paramvir;Wang, Jun;Durbin, Richard
通讯作者：
Durbin, Richard
影响因子：
3.3
作者：
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通讯作者：
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