Immune-Mediated Mechanisms of COVID-19 Neuropathology.
Immune-Mediated Mechanisms of COVID-19 Neuropathology.
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DOI：
10.3389/fneur.2022.882905
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发表时间：
2022
影响因子：
3.4
通讯作者：
Michael, Benedict D.
中科院分区：
文献类型：
--
作者：
Dunai, Cordelia;Collie, Ceryce;Michael, Benedict D.
尽管SARS-CoV-2引起呼吸道病毒感染，但COVID-19患者的神经系统并发症发生率很高。这些症状包括头痛、嗅觉丧失、脑炎和中风。人们对导致这些病理的可能的不同机制知之甚少，迫切需要了解如何预防和治疗它们。本文从免疫系统如何在神经系统并发症中发挥作用的角度探讨了最近的研究，包括细胞因子，血液生物标志物，免疫细胞和自身抗体。我们还讨论了从动物模型中吸取的教训。总的来说，我们强调了从越来越多的证据中出现的两个关键点：（1）SARS-CoV-2在大多数情况下不会侵入大脑，因此相关的神经系统并发症可能来自间接影响，如免疫激活（2）尽管免疫系统在控制病毒方面起着关键作用，但其失调可能导致病理学。
Although SARS-CoV-2 causes a respiratory viral infection, there is a large incidence of neurological complications occurring in COVID-19 patients. These range from headaches and loss of smell to encephalitis and strokes. Little is known about the likely diverse mechanisms causing these pathologies and there is a dire need to understand how to prevent and treat them. This review explores recent research from the perspective of investigating how the immune system could play a role in neurological complications, including cytokines, blood biomarkers, immune cells, and autoantibodies. We also discuss lessons learnt from animal models. Overall, we highlight two key points that have emerged from increasing evidence: (1) SARS-CoV-2 does not invade the brain in the majority of cases and so the associated neurological complications might arise from indirect effects, such as immune activation (2) although the immune system plays a critical role in controlling the virus, its dysregulation can cause pathology.
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影响因子：
1.4
作者：
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通讯作者：
Senne, Carlos
DOI：
10.1038/s41577-020-00458-y
发表时间：
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期刊：
Nature reviews. Immunology
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通讯作者：
García-Sastre A
DOI：
10.1038/s41577-021-00665-1
发表时间：
2022-03
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Afzali B;Noris M;Lambrecht BN;Kemper C
通讯作者：
Kemper C