A Dynamic Simulation of Musculoskeletal Function in the Mouse Hindlimb During Trotting Locomotion.
A Dynamic Simulation of Musculoskeletal Function in the Mouse Hindlimb During Trotting Locomotion.
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DOI：
10.3389/fbioe.2018.00061
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发表时间：
2018
影响因子：
5.7
通讯作者：
Hutchinson JR
中科院分区：
文献类型：
--
作者：
Charles JP;Cappellari O;Hutchinson JR
小鼠经常被用作各种人类神经肌肉疾病的动物模型，对这些模型的分析通常需要详细的步态分析。然而，人们对小鼠肌肉骨骼系统运动过程中的动力学知之甚少。在这项研究中，我们使用计算机优化程序来创建小鼠小跑的模拟，使用先前开发的小鼠后肢肌肉骨骼模型结合新的实验数据，从而可以估计肌肉力量、激活模式和机械功水平。分析整个跨步中的肌肉腱单位 (MTU) 机械功可以更深入地了解它们各自的功能，其中股直肌 MTU 在摆动和站立阶段主导正负机械功的产生。该分析还测试了先前仅根据解剖数据得出的小鼠后肢的功能推论，例如肌肉功能的近远端梯度的存在，被认为反映了对节能运动的适应。结果并不强烈支持小鼠肌肉骨骼系统中存在这种梯度，特别是考虑到踝跖屈肌 MTU 的负净功输出相对较高，尽管更详细的模拟可以进一步测试这一点。这种建模分析为未来通过神经力学模拟的发展来控制脊椎动物运动的研究奠定了基础。
Mice are often used as animal models of various human neuromuscular diseases, and analysis of these models often requires detailed gait analysis. However, little is known of the dynamics of the mouse musculoskeletal system during locomotion. In this study, we used computer optimization procedures to create a simulation of trotting in a mouse, using a previously developed mouse hindlimb musculoskeletal model in conjunction with new experimental data, allowing muscle forces, activation patterns, and levels of mechanical work to be estimated. Analyzing musculotendon unit (MTU) mechanical work throughout the stride allowed a deeper understanding of their respective functions, with the rectus femoris MTU dominating the generation of positive and negative mechanical work during the swing and stance phases. This analysis also tested previous functional inferences of the mouse hindlimb made from anatomical data alone, such as the existence of a proximo-distal gradient of muscle function, thought to reflect adaptations for energy-efficient locomotion. The results do not strongly support the presence of this gradient within the mouse musculoskeletal system, particularly given relatively high negative net work output from the ankle plantarflexor MTUs, although more detailed simulations could test this further. This modeling analysis lays a foundation for future studies of the control of vertebrate movement through the development of neuromechanical simulations.
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影响因子：
3.3
作者：
Bullimore, SR;Burn, JF
通讯作者：
Burn, JF
影响因子：
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3.7
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通讯作者：
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