Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer.
Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer.
复制标题
赖氨酰氧化酶家族成员在肿瘤微环境和肝癌进展中的作用。
DOI：
10.3390/ijms21249751
复制
发表时间：
2020-12-21
影响因子：
5.6
通讯作者：
Chu PY
中科院分区：
文献类型：
--
作者：
Lin HY;Li CJ;Yang YL;Huang YH;Hsiau YT;Chu PY
赖氨酰氧化酶（LOX）家族成员是分泌型铜依赖性胺氧化酶，由LOX和LOX样1 -4（LOXL 1 -4）五种旁系同源物组成，其特征在于催化活性有助于结构性细胞外基质（ECM）交联的重塑。ECM重塑在肿瘤周围血管生成中起关键作用，从而形成腐败的肿瘤微环境（TME）。原发性肝癌包括肝细胞癌（HCC）和胆管癌（CCA），在全球排名第七位，晚期治疗选择有限。近年来，越来越多的证据表明LOX家族成员在肝癌的发病机制和TME的形成中起着关键作用，表明其作为治疗靶点的巨大潜力。本文就LOX家族成员在肝癌的临床应用价值、肿瘤进展及TME中的新生物学作用作一综述。此外，我们强调了最近对它们的机制及其在肝癌靶向治疗发展中的潜在参与的见解。
The lysyl oxidase (LOX) family members are secreted copper-dependent amine oxidases, comprised of five paralogues: LOX and LOX-like l-4 (LOXL1-4), which are characterized by catalytic activity contributing to the remodeling of the cross-linking of the structural extracellular matrix (ECM). ECM remodeling plays a key role in the angiogenesis surrounding tumors, whereby a corrupt tumor microenvironment (TME) takes shape. Primary liver cancer includes hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), ranked as the seventh most common cancer globally, with limited therapeutic options for advanced stages. In recent years, a growing body of evidence has revealed the key roles of LOX family members in the pathogenesis of liver cancer and the shaping of TME, indicating their notable potential as therapeutic targets. We herein review the clinical value and novel biological roles of LOX family members in tumor progression and the TME of liver cancers. In addition, we highlight recent insights into their mechanisms and their potential involvement in the development of target therapy for liver cancer.
登录
查看更多内容
影响因子：
3.7
作者：
Bondareva A;Downey CM;Ayres F;Liu W;Boyd SK;Hallgrimsson B;Jirik FR
通讯作者：
Jirik FR
影响因子：
3.4
作者：
Choi J;Chung T;Rhee H;Kim YJ;Jeon Y;Yoo JE;Noh S;Han DH;Park YN
通讯作者：
Park YN
影响因子：
4.8
作者：
Borel, A;Eichenberger, D;Font, B
通讯作者：
Font, B
影响因子：
4
作者：
Chen, Xiaoping;Kou, Yubin;Pu, Yumei
通讯作者：
Pu, Yumei
LOXL1通过抑制YAP转录活性调节结直肠癌的恶性进展
影响因子：
8.4
作者：
Hu, Lin;Wang, Jing;Chin, Y. Eugene
通讯作者：
Chin, Y. Eugene