Extracellular high-mobility group box 1 is increased in patients with Behçet's disease with intestinal involvement.
Extracellular high-mobility group box 1 is increased in patients with Behçet's disease with intestinal involvement.
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DOI：
10.3346/jkms.2011.26.5.697
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发表时间：
2011-05
影响因子：
4.5
通讯作者：
Koh EM
中科院分区：
文献类型：
--
作者：
Ahn JK;Cha HS;Bae EK;Lee J;Koh EM
高迁移率族蛋白1（HMGB 1）在慢性炎症性疾病如类风湿性关节炎、系统性红斑狼疮等中发挥重要作用。本研究探讨了细胞外HMGB 1表达和疾病活动性之间的关系，以及白塞病（BD）的临床特征。测定42例BD患者血清中HMGB 1的细胞外表达，并与22例年龄和性别匹配的健康对照组进行比较。BD患者的HMGB 1表达显著高于健康对照组（78.70 ± 20.22 vs 10.79 ± 1.90 ng/mL，P = 0.002）。BD患者肠黏膜受累组HMGB 1表达水平（179.61 ± 67.95）ng/mL显著高于无肠黏膜受累组（61.89 ± 19.81）ng/mL（P = 0.04）。未观察到HMGB 1浓度与其他临床表现或疾病活动性之间存在显著相关性。提示细胞外HMGB 1可能在BD的发病机制中起重要作用。
High-mobility group box 1 (HMGB1) protein has been demonstrated to play an important role in chronic inflammatory diseases including rheumatoid arthritis, and systemic lupus erythematosus. This study investigated the association between extracellular HMGB1 expression and disease activity, and clinical features of Behçet's disease (BD). Extracellular HMGB1 expression in the sera of 42 BD patients was measured and was compared to that of 22 age- and sex-matched healthy controls. HMGB1 expression was significantly increased in BD patients compared to healthy controls (78.70 ± 20.22 vs 10.79 ± 1.90 ng/mL, P = 0.002). In addition, HMGB1 expression was significantly elevated in BD patients with intestinal involvement compared to those without (179.61 ± 67.95 vs 61.89 ± 19.81 ng/mL, P = 0.04). No significant association was observed between HMGB1 concentration and other clinical manifestations, or disease activity. It is suggested that extracellular HMGB1 may play an important role in the pathogenesis of BD.
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影响因子：
4.5
作者：
Yi SW;Cheon JH;Kim JH;Lee SK;Kim TI;Lee YC;Kim WH
通讯作者：
Kim WH
影响因子：
29.4
作者：
Sappington, PL;Yang, R;Fink, MP
通讯作者：
Fink, MP
影响因子：
5.5
作者：
Park, JS;Arcaroli, J;Abraham, E
通讯作者：
Abraham, E
影响因子：
4.9
作者：
Pisetsky, David S.;Erlandsson-Harris, Helena;Andersson, Ulf
通讯作者：
Andersson, Ulf
DOI：
10.1084/jem.20030800
发表时间：
2003-11-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chavakis T;Bierhaus A;Al-Fakhri N;Schneider D;Witte S;Linn T;Nagashima M;Morser J;Arnold B;Preissner KT;Nawroth PP
通讯作者：
Nawroth PP