Dual roles of immune cells and their factors in cancer development and progression.
Dual roles of immune cells and their factors in cancer development and progression.
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DOI：
10.7150/ijbs.7.651
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发表时间：
2011
影响因子：
9.2
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Zamarron BF;Chen W
传统观点认为，完整的免疫反应，如免疫监视或免疫编辑，是预防和抑制肿瘤发展所必需的；但最近的证据也表明，未解决的免疫反应，如慢性炎症，可以促进癌症的生长和发展。在免疫系统中，细胞毒性CD8+和CD4+Th1T细胞及其特有的细胞因子干扰素-γ是主要的抗肿瘤免疫效应细胞，而肿瘤相关巨噬细胞()或髓系来源的抑制细胞及其衍生的细胞因子IL-6、肿瘤坏死因子、IL-1β和IL-23通常被认为是主要的促肿瘤力量。然而，Th17细胞、CD4+CD25+Foxp3+调节性T细胞和免疫调节性细胞因子如转化生长因子-β在肿瘤发生和生存中的作用仍不清楚。这些免疫细胞及其产生的细胞因子，包括免疫抑制和炎性细胞因子，在促进或阻止癌症发展方面发挥着双重作用，它们在癌症进展中的最终作用可能在很大程度上依赖于肿瘤微环境和导致癌变初始传播的事件。
Traditional wisdom holds that intact immune responses, such as immune surveillance or immunoediting, are required for preventing and inhibiting tumor development; but recent evidence has also indicated that unresolved immune responses, such as chronic inflammation, can promote the growth and progression of cancer. Within the immune system, cytotoxic CD8+ and CD4+ Th1 T cells, along with their characteristically produced cytokine IFN-γ, function as the major anti-tumor immune effector cells, whereas tumor associated macrophages (TAM) or myeloid-derived suppressive cells (MDSC) and their derived cytokines IL-6, TNF, IL-1β and IL-23 are generally recognized as dominant tumor-promoting forces. However, the roles played by Th17 cells, CD4+ CD25+ Foxp3+ regulatory T lymphocytes and immunoregulatory cytokines such as TGF-β in tumor development and survival remain elusive. These immune cells and the cellular factors produced from them, including both immunosuppressive and inflammatory cytokines, play dual roles in promoting or discouraging cancer development, and their ultimate role in cancer progression may rely heavily on the tumor microenvironment and the events leading to initial propagation of carcinogenesis.
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影响因子：
120.7
作者：
Chen, CJ;Yang, HI;Iloeje, UH
通讯作者：
Iloeje, UH
影响因子：
50.3
作者：
Kortylewski M;Xin H;Kujawski M;Lee H;Liu Y;Harris T;Drake C;Pardoll D;Yu H
通讯作者：
Yu H
影响因子：
4.4
作者：
Dunn, GP;Ikeda, H;Schreiber, RD
通讯作者：
Schreiber, RD
CD4+ CD25+ T（R）细胞通过细胞因子依赖性机制抑制先天的免疫病理。
影响因子：
15.3
作者：
Maloy, KJ;Salaun, L;Cahill, R;Dougan, G;Saunders, NJ;Powrie, F
通讯作者：
Powrie, F
DOI：
10.1084/jem.20030152
发表时间：
2003-12-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chen W;Jin W;Hardegen N;Lei KJ;Li L;Marinos N;McGrady G;Wahl SM
通讯作者：
Wahl SM