CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms.
CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms.
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CD4+ CD25+ T（R）细胞通过细胞因子依赖性机制抑制先天的免疫病理。
DOI：
10.1084/jem.20021345
复制
发表时间：
2003-01-06
影响因子：
15.3
通讯作者：
Powrie, F
中科院分区：
文献类型：
--
作者：
Maloy, KJ;Salaun, L;Cahill, R;Dougan, G;Saunders, NJ;Powrie, F
CD 4 + CD 25+调节性T（TR）细胞可以抑制多种自身免疫性和炎症性疾病，但它们抑制体内免疫应答的确切机制仍未解决。在这里，我们使用肝螺杆菌感染的T细胞重组激活基因（RAG）−/−小鼠作为模型，研究CD 4 + CD 25 + TR细胞抑制细菌引发的肠道炎症的能力。H.肝吸虫感染引起T细胞介导的和T细胞非依赖性的肠道炎症，这两种炎症都被过继转移的CD 4 + CD 25 + TR细胞抑制。T细胞非依赖性病理学伴随着先天免疫系统的激活，其也被CD 4 + CD 25 + TR细胞抑制。先天免疫病理学的抑制依赖于T细胞来源的白细胞介素10，也依赖于转化生长因子β的产生。因此，CD 4 + CD 25 + TR细胞不仅抑制适应性T细胞应答，而且还能够控制由先天免疫机制介导的病理。
CD4+CD25+ regulatory T (TR) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved. Here, we have used Helicobacter hepaticus infection of T cell–reconstituted recombination-activating gene (RAG)−/− mice as a model to study the ability of CD4+CD25+ TR cells to inhibit bacterially triggered intestinal inflammation. H. hepaticus infection elicited both T cell-mediated and T cell–independent intestinal inflammation, both of which were inhibited by adoptively transferred CD4+CD25+ TR cells. T cell–independent pathology was accompanied by activation of the innate immune system that was also inhibited by CD4+CD25+ TR cells. Suppression of innate immune pathology was dependent on T cell–derived interleukin 10 and also on the production of transforming growth factor β. Thus, CD4+CD25+ TR cells do not only suppress adaptive T cell responses, but are also able to control pathology mediated by innate immune mechanisms.
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影响因子：
4.4
作者：
POWRIE, F;LEACH, MW;COFFMAN, RL
通讯作者：
COFFMAN, RL
影响因子：
3.1
作者：
Kullberg, MC;Rothfuchs, AG;Sher, A
通讯作者：
Sher, A
白介素10在抑制肠炎的调节T细胞功能中的重要作用。
影响因子：
15.3
作者：
Asseman, C;Mauze, S;Leach, M W;Coffman, R L;Powrie, F
通讯作者：
Powrie, F
影响因子：
3.1
作者：
Beckwith, CS;McGee, DJ;Riley, LK
通讯作者：
Riley, LK
影响因子：
32.4
作者：
POWRIE, F;LEACH, MW;COFFMAN, RL
通讯作者：
COFFMAN, RL