Influence of editing pulse flip angle on J-difference MR spectroscopy.
Influence of editing pulse flip angle on J-difference MR spectroscopy.
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DOI：
10.1002/mrm.29008
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发表时间：
2022-03
影响因子：
3.3
通讯作者：
Edden RAE
中科院分区：
文献类型：
--
作者：
Tapper S;Hui SCN;Saleh MG;Zöllner HJ;Oeltzschner G;Near J;Soher BJ;Edden RAE
研究编辑脉冲翻转角对编辑效率的依赖性，并最终最大化常用编辑 MRS 信号（如 GABA 和乳酸）的编辑信号。对一系列自旋系统进行了密度矩阵模拟，以找到最大编辑效率的编辑脉冲翻转角 (FA)。使用 3T Philips 扫描仪对 10 名健康参与者进行的体模实验和体内测量证实了模拟结果。针对 GABA+ 和乳酸进行了四次 MEGA-PRESS 体内测量，将传统编辑脉冲翻转角度 (FA = 180°) 与模拟建议的最佳角度 (FA = 210°) 进行比较。模拟和模型实验表明，编辑后的 GABA 和乳酸信号在 FA = 210° 时最大。与传统编辑（FA = 180°）相比，来自 GABA+ 和乳酸信号的体内信号平均分别增加了 8.5% 和 9.3%。将 MEGA-PRESS 实验中编辑脉冲的翻转角从 180° 增加到 210°，体内来自 GABA+ 和乳酸的编辑信号增加了约 9%。
To investigate the editing-pulse flip angle dependence of editing efficiency and ultimately to maximize the edited signal of commonly edited MRS signals such as GABA and lactate. Density-matrix simulations were performed for a range of spin systems to find the editing-pulse flip angle (FA) for maximal editing efficiency. Simulations were confirmed by phantom experiments and in vivo measurements in 10 healthy participants using a 3T Philips scanner. Four MEGA-PRESS in vivo measurements targeting GABA+ and lactate were performed, comparing the conventional editing-pulse flip angle (FA = 180°) to the optimal one suggested by simulations (FA = 210°). Simulations and phantom experiments show that edited GABA and lactate signals are maximal at FA = 210°. Compared to conventional editing (FA = 180°), in vivo signals from GABA+ and lactate signals increase on average by 8.5% and 9.3%, respectively. Increasing the flip angle of editing-pulses in the MEGA-PRESS experiment from 180° to 210° increases the edited signals from GABA+ and lactate by about 9% in vivo.
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影响因子：
5.7
作者：
Mikkelsen M;Barker PB;Bhattacharyya PK;Brix MK;Buur PF;Cecil KM;Chan KL;Chen DY;Craven AR;Cuypers K;Dacko M;Duncan NW;Dydak U;Edmondson DA;Ende G;Ersland L;Gao F;Greenhouse I;Harris AD;He N;Heba S;Hoggard N;Hsu TW;Jansen JFA;Kangarlu A;Lange T;Lebel RM;Li Y;Lin CE;Liou JK;Lirng JF;Liu F;Ma R;Maes C;Moreno-Ortega M;Murray SO;Noah S;Noeske R;Noseworthy MD;Oeltzschner G;Prisciandaro JJ;Puts NAJ;Roberts TPL;Sack M;Sailasuta N;Saleh MG;Schallmo MP;Simard N;Swinnen SP;Tegenthoff M;Truong P;Wang G;Wilkinson ID;Wittsack HJ;Xu H;Yan F;Zhang C;Zipunnikov V;Zöllner HJ;Edden RAE
通讯作者：
Edden RAE
影响因子：
2.2
作者：
Star-Lack, J;Spielman, D;Vigneron, DB
通讯作者：
Vigneron, DB
影响因子：
4.4
作者：
Edden, Richard A. E.;Puts, Nicolaas A. J.;Harris, Ashley D.;Barker, Peter B.;Evans, C. John
通讯作者：
Evans, C. John
影响因子：
2.9
作者：
Mikkelsen M;Tapper S;Near J;Mostofsky SH;Puts NAJ;Edden RAE
通讯作者：
Edden RAE
影响因子：
3
作者：
Mikkelsen, Mark;Loo, Rachelle S.;Harris, Ashley D.
通讯作者：
Harris, Ashley D.