Big GABA: Edited MR spectroscopy at 24 research sites.
Big GABA: Edited MR spectroscopy at 24 research sites.
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DOI：
10.1016/j.neuroimage.2017.07.021
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发表时间：
2017-10-01
期刊：
影响因子：
5.7
通讯作者：
Edden RAE
中科院分区：
文献类型：
--
作者：
Mikkelsen M;Barker PB;Bhattacharyya PK;Brix MK;Buur PF;Cecil KM;Chan KL;Chen DY;Craven AR;Cuypers K;Dacko M;Duncan NW;Dydak U;Edmondson DA;Ende G;Ersland L;Gao F;Greenhouse I;Harris AD;He N;Heba S;Hoggard N;Hsu TW;Jansen JFA;Kangarlu A;Lange T;Lebel RM;Li Y;Lin CE;Liou JK;Lirng JF;Liu F;Ma R;Maes C;Moreno-Ortega M;Murray SO;Noah S;Noeske R;Noseworthy MD;Oeltzschner G;Prisciandaro JJ;Puts NAJ;Roberts TPL;Sack M;Sailasuta N;Saleh MG;Schallmo MP;Simard N;Swinnen SP;Tegenthoff M;Truong P;Wang G;Wilkinson ID;Wittsack HJ;Xu H;Yan F;Zhang C;Zipunnikov V;Zöllner HJ;Edden RAE
磁共振波谱（MRS）是唯一可以无创检测人脑中神经递质γ-氨基丁酸（GABA）内源性信号的生物医学成像方法。它的日益普及得到了扫描仪硬件和采集方法的改进，以及更广泛地获得可以选择性地检测GABA的脉冲序列，特别是J-差异光谱编辑序列的帮助。然而，GABA编辑的MRS的实施在研究中心之间仍然存在差异，使得研究之间的比较具有挑战性。这项大规模的多供应商、多地点研究旨在更好地了解影响GABA编辑的MRS测量结果的因素。来自272名健康成年人的数据在三家主要MRI供应商的扫描仪上获得，并使用Gannet处理管道进行分析。MRS数据在内侧顶叶中用标准GABA+和大分子-（MM-）抑制的GABA编辑获得。整个队列的变异系数为12%的GABA+测量和28%的MM抑制GABA测量。一个多层次的分析表明，在GABA+数据的方差（72%）占的参与者之间的差异内网站，而网站水平的差异占相对更多的方差（20%）比供应商水平的差异（8%）。对于MM抑制GABA数据，方差平均分布在站点（50%）和参与者水平（50%）差异之间。研究结果表明，GABA+测量表现出很强的一致性时，实施与标准协议。然而，MM抑制GABA测量的变异性增加，这部分归因于站点间数据采集的差异。这项研究的协议建立了一个框架，为未来的GABA编辑MRS的方法标准化，而结果提供了宝贵的基准MRS社区。
Magnetic resonance spectroscopy (MRS) is the only biomedical imaging method that can noninvasively detect endogenous signals from the neurotransmitter γ-aminobutyric acid (GABA) in the human brain. Its increasing popularity has been aided by improvements in scanner hardware and acquisition methodology, as well as by broader access to pulse sequences that can selectively detect GABA, in particular J-difference spectral editing sequences. Nevertheless, implementations of GABA-edited MRS remain diverse across research sites, making comparisons between studies challenging. This large-scale multi-vendor, multi-site study seeks to better understand the factors that impact measurement outcomes of GABA-edited MRS. An international consortium of 24 research sites was formed. Data from 272 healthy adults were acquired on scanners from the three major MRI vendors and analyzed using the Gannet processing pipeline. MRS data were acquired in the medial parietal lobe with standard GABA+ and macromolecule- (MM-) suppressed GABA editing. The coefficient of variation across the entire cohort was 12% for GABA+ measurements and 28% for MM-suppressed GABA measurements. A multilevel analysis revealed that most of the variance (72%) in the GABA+ data was accounted for by differences between participants within-site, while site-level differences accounted for comparatively more variance (20%) than vendor-level differences (8%). For MM-suppressed GABA data, the variance was distributed equally between site- (50%) and participant-level (50%) differences. The findings show that GABA+ measurements exhibit strong agreement when implemented with a standard protocol. There is, however, increased variability for MM-suppressed GABA measurements that is attributed in part to differences in site-to-site data acquisition. This study’s protocol establishes a framework for future methodological standardization of GABA-edited MRS, while the results provide valuable benchmarks for the MRS community.
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影响因子：
2.5
作者：
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通讯作者：
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影响因子：
3.3
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Deelchand, Dinesh K.;Adanyeguh, Isaac M.;Emir, Uzay E.;Nguyen, Tra-My;Valabregue, Romain;Henry, Pierre-Gilles;Mochel, Fanny;Oez, Guelin
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3T 下大分子抑制 GABA 编辑的前瞻性频率校正。
影响因子：
4.4
作者：
Edden, Richard A. E.;Oeltzschner, Georg;Harris, Ashley D.;Puts, Nicolaas A. J.;Chan, Kimberly L.;Boer, Vincent O.;Schar, Michael;Barker, Peter B.
通讯作者：
Barker, Peter B.
影响因子：
4.4
作者：
Edden, Richard A. E.;Puts, Nicolaas A. J.;Harris, Ashley D.;Barker, Peter B.;Evans, C. John
通讯作者：
Evans, C. John
影响因子：
3.3
作者：
Chan, Kimberly L.;Puts, Nicolaas A. J.;Edden, Richard A. E.
通讯作者：
Edden, Richard A. E.