Using c-Fos immunocytochemistry to identify forebrain regions that may inhibit maternal behavior in rats.

Using c-Fos immunocytochemistry to identify forebrain regions that may inhibit maternal behavior in rats.
复制标题

使用 c-Fos 免疫细胞化学来识别可能抑制大鼠母性行为的前脑区域。

DOI:
10.1037//0735-7044.114.2.337
复制
发表时间:
2000
影响因子:
1.9
通讯作者:
M. Numan
M. Numan
中科院分区:
医学4区
文献类型:
--
作者:
Teige P. Sheehan;J. Cirrito;M. J. Numan;M. Numan

文献摘要

参考文献

被引文献

相似文献

有证据表明,处女大鼠存在一种神经系统,可以抑制母性行为。已有研究表明,妊娠激素通过减少这一系统的行为影响来促进母性行为的发生。作者使用c-Fos免疫细胞化学来识别非母系大鼠比母系大鼠更容易受到幼崽暴露的脑区。先前的实验表明,其中一些区域,如杏仁背内侧核和几个下丘脑内侧部位,抑制了母亲的行为。对于其他核,如腹侧隔核、乳头体前背侧核和终纹主床核,这是它们也可以抑制母体反应的第一个迹象。这些区域以前被认为与促进防御行为有关,这与非母体大鼠主动避开幼鼠的发现一致。这些发现表明,幼鼠暴露于幼崽可以促进处女大鼠的防御反应的神经回路的存在,以及怀孕荷尔蒙如何减少这种活动来刺激母体行为。
Evidence indicates there is a neural system that inhibits maternal behavior in virgin rats. It has been suggested that pregnancy hormones promote the onset of maternal behavior by reducing the behavioral influence of this system. The authors used c-Fos immunocytochemistry to identify brain regions more activated by pup exposure in nonmaternal rats than in maternal rats. Previous experiments indicated that some of these regions, such as the posterodorsal medial amygdala and several medial hypothalamic sites, inhibit maternal behavior. For others, such as the ventral lateral septum, dorsal premammillary nucleus, and principal bed nucleus of the stria terminalis, this is the first indication that they could also inhibit maternal responding. These regions have previously been implicated in promoting defensive behaviors, consistent with the finding that nonmaternal rats actively avoid pups. These findings suggest the existence of a neural circuit through which pup exposure could promote defensive responses in virgin rats, and how pregnancy hormones could reduce such activity to stimulate maternal behavior.
卵巢内分泌状态调节地西泮的抗焦虑效力和γ-氨基丁酸-苯二氮卓受体介导的氯离子转运的功效。
DOI: 10.1037//0735-7044.105.5.653
发表时间: 1991
影响因子: 1.9
作者:
Bitran,D;Hilvers,RJ;Kellogg,CK
通讯作者: Kellogg,CK
核原癌基因的类固醇激素调节。
DOI: 10.1210/edrv-14-6-659
发表时间: 1993
期刊: Endocrine reviews
影响因子: 20.3
作者:
Schuchard,M;Landers,JP;Sandhu,NP;Spelsberg,TC
通讯作者: Spelsberg,TC
怀孕期间雌性大鼠行为相关大脑区域的雌激素受体免疫反应水平发生变化。
DOI: 10.1016/s0169-328x(96)00141-6
发表时间: 1996
期刊: Brain research. Molecular brain research
影响因子: --
作者:
Wagner,CK;Morrell,JI
通讯作者: Morrell,JI
DOI: 10.1016/s0166-2236(98)01265-x
发表时间: 1998-08-01
影响因子: 15.9
作者:
Swanson, LW;Petrovich, GD
通讯作者: Petrovich, GD
促肾上腺皮质激素释放激素抑制母体行为并诱导幼崽死亡。
DOI: 10.1016/0024-3205(91)90278-j
发表时间: 1991
期刊: Life sciences
影响因子: 6.1
作者:
Pedersen,CA;Caldwell,JD;McGuire,M;Evans,DL
通讯作者: Evans,DL