Esophageal disease in AIDS is associated with pathologic processes rather than mucosal human immunodeficiency virus type 1.

Esophageal disease in AIDS is associated with pathologic processes rather than mucosal human immunodeficiency virus type 1.
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艾滋病中的食管疾病与病理过程有关,而不是与 1 型粘膜人类免疫缺陷病毒有关。

DOI:
--
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发表时间:
1993
影响因子:
6.4
通讯作者:
Cecil F. Fox
Cecil F. Fox
中科院分区:
医学2区
文献类型:
--
作者:
Phillip D. Smith;Mark S. Eisner;J. Manischewitz;Vee J. Gill;Henry Masur;Cecil F. Fox

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对25例有食管症状的艾滋病患者进行食管疾病和食管黏膜人类免疫缺陷病毒1型(HIV-1)的评估。在20例患者中发现了由白色念珠菌、巨细胞病毒、单纯疱疹病毒、水痘-带状疱疹病毒或鸟分枝杆菌-细胞内复合物引起的单一感染过程,或由卡波西氏肉瘤或反流性食管炎引起的单一非感染性过程。在5例患者中发现了两个过程。36%的患者食管固有层单个核细胞采用原位杂交检测到HIV-1 mRNA。食管黏膜中HIV-1的存在与特定的食管症状、粘膜炎症或溃疡、卡波西氏肉瘤、特定的机会性感染或感染对治疗的反应无关。艾滋病患者的食道疾病似乎与特定的病理过程有关,而不是与食管黏膜中HIV-1的存在有关。
Twenty-five patients with AIDS and esophageal symptoms were evaluated for the presence of esophageal disease and human immunodeficiency virus type 1 (HIV-1) in the esophageal mucosa. A single infectious process caused by Candida albicans, cytomegalovirus, herpes simplex virus, varicella-zoster virus, or Mycobacterium avium-intracellulare complex or a single noninfectious process caused by Kaposi's sarcoma or reflux esophagitis was identified in 20 patients. Two processes were identified in 5 patients. HIV-1 mRNA was detected by in situ hybridization in mononuclear cells in esophageal lamina propria in 36% of patients. The presence of HIV-1 in the esophageal mucosa was not associated with a specific esophageal symptom, mucosal inflammation or ulceration, Kaposi's sarcoma, specific opportunistic infection, or response of the infection(s) to therapy. Esophageal disease in patients with AIDS appears to be associated with specific pathologic processes rather than the presence of HIV-1 in esophageal mucosa.
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