Intestinal dysbiosis is common in systemic sclerosis and associated with gastrointestinal and extraintestinal features of disease.
Intestinal dysbiosis is common in systemic sclerosis and associated with gastrointestinal and extraintestinal features of disease.
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DOI：
10.1186/s13075-016-1182-z
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发表时间：
2016-11-29
影响因子：
4.9
通讯作者：
Marsal J
中科院分区：
文献类型：
--
作者：
Andréasson K;Alrawi Z;Persson A;Jönsson G;Marsal J
最近的证据表明，在包括系统性硬化症(SSC)在内的几种风湿性疾病中，自身免疫与肠道微生物组成之间存在联系。这项研究的目的是调查SSC中肠道生物失调的患病率，并描述患有这种潜在的免疫调节偏差的患者的特征。这项研究包括98名连续接受住院治疗的患者。使用经过验证的基于基因组的微生物群测试(GA-MAP™生态平衡测试，遗传分析，挪威奥斯陆)分析粪便样本中的肠道微生物区系组成。根据这项标准化测试，发现存在肠道微生物区系失调。通过临床、实验室和放射检查检查患者的胃肠道和肠外表现，包括食道放射摄影、营养不良通用筛查工具(MUST)、血浆转甲状腺素(营养不良的标志)和粪便(F-)钙保护素(肠道炎症的标志)的水平。大多数患者(75.5%)表现出生物失调。在食道动力障碍患者中，微生态失调更为严重(rS = 为0.31，p = 为0.001)，且更为常见(p = 为0.013)。在血浆转甲状腺素水平异常(p = 0.045)或微量营养素缺乏(p = 0.009)的患者中，生物失调也更为明显。根据SIME，在19名有营养不良风险的患者中，18人出现了生物失调。相反，在24名营养不良测试呈阴性的患者中，只有一人有营养不良的风险。在代谢试验阳性和阴性患者中，F-钙保护素的平均 ± 扫描电子显微镜水平分别为112 ± 14和45 ± 8μg/g。皮肤毛细血管扩张(p = 0.020)、凹陷性疤痕(p = 0.023)、肺纤维化(p = 0.009)和血清炎症标记物升高(p <； 0.001)的患者的生物失调更为严重。然而，生物失调与年龄、病程、疾病亚型或皮肤纤维化程度无关。在这项横断面研究中，SSC患者普遍存在肠道生物失调，并与胃肠功能障碍、营养不良以及SSC的一些炎性、纤维化和血管外特征有关。需要进一步的研究来阐明肠道微生物-宿主相互作用在这种自身免疫性疾病中的潜在因果关系。
Recent evidence suggests a link between autoimmunity and the intestinal microbial composition in several rheumatic diseases including systemic sclerosis (SSc). The objective of this study was to investigate the prevalence of intestinal dysbiosis in SSc and to characterise patients suffering from this potentially immunomodulatory deviation. This study consisted of 98 consecutive patients subject to in-hospital care. Stool samples were analysed for intestinal microbiota composition using a validated genome-based microbiota test (GA-map™ Dysbiosis Test, Genetic Analysis, Oslo, Norway). Gut microbiota dysbiosis was found present as per this standardised test. Patients were examined regarding gastrointestinal and extraintestinal manifestations of SSc by clinical, laboratory, and radiological measures including esophageal cineradiography, the Malnutrition Universal Screening Tool (MUST), levels of plasma transthyretin (a marker of malnutrition) and faecal (F-) calprotectin (a marker of intestinal inflammation). A majority (75.5%) of the patients exhibited dysbiosis. Dysbiosis was more severe (rs = 0.31, p = 0.001) and more common (p = 0.013) in patients with esophageal dysmotility. Dysbiosis was also more pronounced in patients with abnormal plasma levels of transthyretin (p = 0.045) or micronutrient deficiency (p = 0.009). In 19 patients at risk for malnutrition according to the MUST, 18 exhibited dysbiosis. Conversely, of the 24 patients with a negative dysbiosis test, only one was at risk for malnutrition. The mean ± SEM levels of F-calprotectin were 112 ± 14 and 45 ± 8 μg/g in patients with a positive and negative dysbiosis test, respectively. Dysbiosis was more severe in patients with skin telangiectasias (p = 0.020), pitting scars (p = 0.023), pulmonary fibrosis (p = 0.009), and elevated serum markers of inflammation (p < 0.001). However, dysbiosis did not correlate with age, disease duration, disease subtype, or extent of skin fibrosis. In this cross-sectional study, intestinal dysbiosis was common in patients with SSc and was associated with gastrointestinal dysfunction, malnutrition and with some inflammatory, fibrotic and vascular extraintestinal features of SSc. Further studies are needed to elucidate the potential causal relationship of intestinal microbe-host interaction in this autoimmune disease.
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影响因子：
2.4
作者：
Manz M;Burri E;Rothen C;Tchanguizi N;Niederberger C;Rossi L;Beglinger C;Lehmann FS
通讯作者：
Lehmann FS
DOI：
10.3945/an.115.008508
发表时间：
2015-09
期刊：
Advances in nutrition (Bethesda, Md.)
影响因子：
--
作者：
Ingenbleek Y;Bernstein LH
通讯作者：
Bernstein LH
影响因子：
4.3
作者：
Moreno Chulilla, Jose Antonio;Romero Colas, Maria Soledad;Gutierrez Martin, Martin
通讯作者：
Gutierrez Martin, Martin
影响因子：
27.4
作者：
Krause, Lijana;Becker, Mike O.;Riemekasten, Gabriela
通讯作者：
Riemekasten, Gabriela
影响因子：
2.5
作者：
Alipour, Beitullah;Homayouni-Rad, Aziz;Mohtadi-Nia, Javad
通讯作者：
Mohtadi-Nia, Javad