The emerging landscape of circular RNA in life processes.
The emerging landscape of circular RNA in life processes.
复制标题
生命过程中环状RNA的新兴景观
DOI：
10.1080/15476286.2016.1220473
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发表时间：
2017-08-03
期刊：
影响因子：
4.1
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Qu S;Zhong Y;Shang R;Zhang X;Song W;Kjems J;Li H
摘要 环状 RNA (circRNA) 是一类新型非编码 RNA，呈现共价闭合连续构象。此前，CircRNA被认为是由于丰度低和技术限制而导致剪接错误的副产品。近年来，随着高通量测序技术的发展，在许多物种中发现了大量的circRNA。最近的研究表明，circRNA 稳定且广泛表达，并且经常表现出细胞类型特异性或组织特异性表达。大多数 circRNA 可以由外显子、内含子或两者生成。值得注意的是，新出现的证据表明，一些 circRNA 可以充当 microRNA (miRNA) 海绵，调节转录或剪接，并可以与 RNA 结合蛋白 (RBP) 相互作用。此外，据报道，circRNA 在多种生命过程中发挥着重要作用，例如衰老、胰岛素分泌、组织发育、动脉粥样硬化性血管疾病风险、心脏肥大和癌症。尽管 circRNA 是古老的分子，但它们代表了一种新近被重视的非编码 RNA 形式，因此在临床和研究领域具有巨大的潜在影响。在此，我们回顾一下目前对circRNA分类、功能以及在生理和病理过程中的意义的认识。我们相信，未来的研究将增加我们对这些新型分子的调控和功能的理解。
abstract Circular RNAs (circRNAs) are a novel class of non-coding RNA that assumes a covalently closed continuous conformation. CircRNAs were previously thought to be the byproducts of splicing errors caused by low abundance and the technological limitations. With the recent development of high-throughput sequencing technology, numerous circRNAs have been discovered in many species. Recent studies have revealed that circRNAs are stable and widely expressed, and often exhibit cell type-specific or tissue-specific expression. Most circRNAs can be generated from exons, introns, or both. Remarkably, emerging evidence indicates that some circRNAs can serve as microRNA (miRNA) sponges, regulate transcription or splicing, and can interact with RNA binding proteins (RBPs). Moreover, circRNAs have been reported to play essential roles in myriad life processes, such as aging, insulin secretion, tissue development, atherosclerotic vascular disease risk, cardiac hypertrophy and cancer. Although circRNAs are ancient molecules, they represent a newly appreciated form of noncoding RNA and as such have great potential implications in clinical and research fields. Here, we review the current understanding of circRNA classification, function and significance in physiological and pathological processes. We believe that future research will increase our understanding of the regulation and function of these novel molecules.
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影响因子：
14.9
作者：
Danan M;Schwartz S;Edelheit S;Sorek R
通讯作者：
Sorek R
影响因子：
4.5
作者：
Burd CE;Jeck WR;Liu Y;Sanoff HK;Wang Z;Sharpless NE
通讯作者：
Sharpless NE
影响因子：
4.4
作者：
Broadbent KM;Broadbent JC;Ribacke U;Wirth D;Rinn JL;Sabeti PC
通讯作者：
Sabeti PC
DOI：
10.1146/annurev.pathol.4.110807.092222
发表时间：
2009
期刊：
Annual review of pathology
影响因子：
--
作者：
Lee YS;Dutta A
通讯作者：
Dutta A
影响因子：
7.3
作者：
Chen, Iju;Chen, Chia-Ying;Chuang, Trees-Juen
通讯作者：
Chuang, Trees-Juen