Hypertriglyceridemic hyperapoB and the development and resolution of nonalcoholic fatty liver disease: a cohort study.
Hypertriglyceridemic hyperapoB and the development and resolution of nonalcoholic fatty liver disease: a cohort study.
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DOI：
10.1016/j.jlr.2023.100418
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发表时间：
2023-08
影响因子：
6.5
通讯作者：
Wang, Tiange
中科院分区：
文献类型：
--
作者：
Wang, Yiying;Kong, Lijie;Ye, Chaojie;Dou, Chun;Li, Mian;Zhao, Zhiyun;Xu, Yu;Lu, Jieli;Chen, Yuhong;Xu, Min;Wang, Weiqing;Ning, Guang;Bi, Yufang;Wang, Tiange
高甘油三酯血症性高载脂蛋白B是一种以低高密度脂蛋白胆固醇、高甘油三酯、高载脂蛋白B、低密度脂蛋白胆固醇/载脂蛋白B比值为特征的不良脂蛋白表型。我们调查了高甘油三酯血症高载脂蛋白B与非酒精性脂肪性肝病(NAFLD)的发病率和消退之间是否存在关联，以及在多大程度上存在关联。这项前瞻性队列研究包括2010至2015年间40岁及以上的9019名中国参与者。采用Logistic回归模型分析高甘油三酯血症、高载脂蛋白B脂蛋白表型和个体脂蛋白参数与NAFLD发病和消退的优势比(OR)。在中位数4.3年的随访中，与最佳表型的参与者相比，高甘油三酯血症高载脂蛋白B参与者发生NAFLD和缓解NAFLD的完全调整OR(95%顺式)分别为2.75(1.91，3.95)和0.57(0.33，1.00)。这些关联在不同人口统计、生活方式和代谢状态的亚组参与者中是一致的。单独地，高密度脂蛋白胆固醇(OR：0.98；95%CI：0.97，0.99)、自然对数转化甘油三酯(1.89；1.52，2.36)和载脂蛋白B(1.006；1.002，1.011)的每单位增加与非酒精性脂肪肝的发病率独立相关，只有甘油三酯(0.77；0.60，0.99)与非酒精性脂肪肝的解决独立相关。我们的研究结果表明，患有高甘油三酯血症性高载脂蛋白B的中国成年人患NAFLD的风险更高，NAFLD解决的可能性更低。在不同人口学、生活方式和代谢状态的成年人中，这些相关性是稳定的，支持高甘油三酯血症高载脂蛋白B作为预防和控制NAFLD的有价值的临床标志物。
Hypertriglyceridemic hyperapoB is an adverse lipoprotein phenotype characterized by low high density lipoprotein (HDL) cholesterol, high triglycerides, high apolipoprotein B (ApoB), and low low density lipoprotein (LDL) cholesterol to ApoB ratio. We investigated whether and to what extent hypertriglyceridemic hyperapoB associates with the incidence and resolution of nonalcoholic fatty liver disease (NAFLD). This prospective cohort study included 9,019 Chinese participants 40 years or older, from 2010 to 2015. Logistic regression models were used to examine the odds ratios (ORs) for the incidence and resolution of NAFLD associated with the hypertriglyceridemic hyperapoB lipoprotein phenotype and individual lipid and lipoprotein parameters. During a median 4.3 years of follow-up, compared with participants with optimal phenotype, the fully adjusted ORs (95% CIs) for participants with hypertriglyceridemic hyperapoB were 2.75 (1.91, 3.95) and 0.57 (0.33, 1.00) for incidence and resolution of NAFLD, respectively. These associations were consistent across subgroup participants with varied demographic, lifestyle, and metabolic status. Individually, each unit increase in HDL cholesterol (OR: 0.98; 95% CI: 0.97, 0.99), natural logarithm-transformed triglycerides (1.89; 1.52, 2.36), and ApoB (1.006; 1.002, 1.011) was independently associated with NAFLD incidence, and only triglycerides (0.77; 0.60, 0.99) was independently associated with NAFLD resolution. Our findings suggest that Chinese adults with hypertriglyceridemic hyperapoB have a higher risk of NAFLD incidence and a lower likelihood of NAFLD resolution. These associations were stable among adults with different demographic, lifestyle, and metabolic status, supporting hypertriglyceridemic hyperapoB as a valuable clinical marker for the prevention and control of NAFLD.
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影响因子：
25.7
作者：
Ioannou, George N.
通讯作者：
Ioannou, George N.
影响因子：
13.1
作者：
Pencina, Karol M.;Pencina, Michael J.;Sniderman, Allan D.
通讯作者：
Sniderman, Allan D.
DOI：
10.1007/s00018-018-2860-6
发表时间：
2018-09
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
Ipsen DH;Lykkesfeldt J;Tveden-Nyborg P
通讯作者：
Tveden-Nyborg P
影响因子：
5.3
作者：
Bao, Yuqian;Lu, Junxi;Xiang, Kunsan
通讯作者：
Xiang, Kunsan
影响因子：
12.6
作者：
Tavaglione, Federica;Jamialahmadi, Oveis;Mancina, Rosellina Margherita
通讯作者：
Mancina, Rosellina Margherita