Is Lesion of Exner’s Area Linked to Progressive Agraphia in Amyotrophic Lateral Sclerosis with Dementia? An Autopsy Case Report
Is Lesion of Exner’s Area Linked to Progressive Agraphia in Amyotrophic Lateral Sclerosis with Dementia? An Autopsy Case Report
复制标题
埃克斯纳区病变与肌萎缩侧索硬化症伴痴呆的进行性失写症有关吗？
作者：
K. Ishihara;H. Ichikawa;Yoshio Suzuki;J. Shiota;I. Nakano;M. Kawamura
失写症作为ALS，尤其是ALS伴痴呆（ALS-D）的一种神经心理学症状，近年来受到越来越多的关注。然而，负责的脑损伤尚未确定。在这里，我们提出了一个明显的失写症，没有失语症的患者ALS-D的尸检病例，也提出了脑脊液变性与TDP-43-病理学与ALS-D兼容。在运动前额叶皮质中，左侧额中回尾侧区或Exner区的变性和免疫组织化学病理最为明显。确保这一地区发挥了关键作用，在汉字和假名的形成用于书写日语，这一情况下的ALS-D显示失写症和埃克斯纳区强调病理损伤。因此，这可能是第一个案件，以表明神经心理症状和相关的损害ALS-D之间的密切关系。
Agraphia, as a neuropsychological symptom of ALS, especially ALS with dementia (ALS-D), has recently attracted more attention. However, the brain lesion responsible has not been identified. Here we present an autopsy case of ALS-D of a patient with obvious agraphia, without aphasia, that also presented cerebrospinal degeneration with TDP-43-pathology compatible with ALS-D. Of the pre-motor frontal lobe cortices, degeneration and immuno-histochemical pathology were most obvious in the caudal area of the left middle frontal gyrus, or Exner’s area. Assuring this area plays a pivotal role in the kanji and kana formation used in writing the Japanese language, this case of ALS-D showed both agraphia and Exner's area stressed pathological lesions. It may thus be the first case to indicate an intimate relationship between the neuropsychological symptoms and an associated lesion for ALS-D.
影响因子：
9.9
作者：
R. Faber
通讯作者：
R. Faber
影响因子：
14.5
作者：
ANDERSON, SW;DAMASIO, AR;DAMASIO, H
通讯作者：
DAMASIO, H