Association Between Proteomic Blood Biomarkers and DTI/NODDI Metrics in Adolescent Football Players: A Pilot Study.
Association Between Proteomic Blood Biomarkers and DTI/NODDI Metrics in Adolescent Football Players: A Pilot Study.
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DOI：
10.3389/fneur.2020.581781
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发表时间：
2020
影响因子：
3.4
通讯作者：
Cheng H
中科院分区：
文献类型：
--
作者：
Kawata K;Steinfeldt JA;Huibregtse ME;Nowak MK;Macy JT;Kercher K;Rettke DJ;Shin A;Chen Z;Ejima K;Newman SD;Cheng H
虽然神经影像学和血液生物标志物一直是神经创伤领域最活跃的两个研究领域，但这些领域很少交叉描述亚震荡性脑损伤。该研究的目的是检查扩散MRI技术[扩散张量成像（DTI）和神经突方向/分散密度成像（NODDI）]与高中足球运动员基线时脑损伤血液生物标志物水平[tau，神经递质光（NfL），胶质细胞酸性蛋白（GFAP）]之间的关联，旨在检测前几个赛季累积的神经元损伤。二十五名足球运动员参加了这项研究。MRI测量和血液样本是在季前赛数据收集过程中获得的。对6个弥散指标进行全脑、基于束的空间统计：各向异性分数（FA）、平均弥散度（MD）、轴向/径向弥散度（AD、RD）、神经突密度指数（NDI）和方向弥散指数（ODI）。5名运动员不适合进行MRI，3份血清样本因溶血而被排除，从而获得17个完整的扩散指标和血液生物标志物水平集，用于相关性分析。我们的基于排列的回归模型显示，血清tau水平与各种轴突束中的MD和NDI显著相关;具体而言，血清tau水平升高与胼胝体和周围白色物质束（例如，纵束）。此外，NfL和ODI在纵束的焦点区域之间存在负相关。我们的数据表明，高中橄榄球运动员可能会在胼胝体和周围的白色物质束（例如纵束）中出现轴突显微结构异常。未来的研究是必要的，以确定响应重复暴露于运动相关的头部冲击的纵向多模态关系。
While neuroimaging and blood biomarker have been two of the most active areas of research in the neurotrauma community, these fields rarely intersect to delineate subconcussive brain injury. The aim of the study was to examine the association between diffusion MRI techniques [diffusion tensor imaging (DTI) and neurite orientation/dispersion density imaging (NODDI)] and brain-injury blood biomarker levels [tau, neurofilament-light (NfL), glial-fibrillary-acidic-protein (GFAP)] in high-school football players at their baseline, aiming to detect cumulative neuronal damage from prior seasons. Twenty-five football players were enrolled in the study. MRI measures and blood samples were obtained during preseason data collection. The whole-brain, tract-based spatial statistics was conducted for six diffusion metrics: fractional anisotropy (FA), mean diffusivity (MD), axial/radial diffusivity (AD, RD), neurite density index (NDI), and orientation dispersion index (ODI). Five players were ineligible for MRIs, and three serum samples were excluded due to hemolysis, resulting in 17 completed set of diffusion metrics and blood biomarker levels for association analysis. Our permutation-based regression model revealed that serum tau levels were significantly associated with MD and NDI in various axonal tracts; specifically, elevated serum tau levels correlated to elevated MD (p = 0.0044) and reduced NDI (p = 0.016) in the corpus callosum and surrounding white matter tracts (e.g., longitudinal fasciculus). Additionally, there was a negative association between NfL and ODI in the focal area of the longitudinal fasciculus. Our data suggest that high school football players may develop axonal microstructural abnormality in the corpus callosum and surrounding white matter tracts, such as longitudinal fasciculus. A future study is warranted to determine the longitudinal multimodal relationship in response to repetitive exposure to sports-related head impacts.
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影响因子：
8.2
作者：
Kawata, Keisuke;Liu, Charles Y.;Merkel, Steven F.;Ramirez, Servio H.;Tierney, Ryan T.;Langford, Dianne
通讯作者：
Langford, Dianne
严重抑郁症患者的分数各向异性降低，并与血管僵硬相关。
DOI：
10.1016/j.nicl.2017.01.013
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Hermesdorf M;Berger K;Szentkirályi A;Schwindt W;Dannlowski U;Wersching H
通讯作者：
Wersching H
影响因子：
48
作者：
Bazarian, Jeffrey J.;Biberthaler, Peter;Jagoda, Andy S.
通讯作者：
Jagoda, Andy S.
影响因子：
4.1
作者：
Joseph, Jacob R.;Swallow, Jennylee S.;Broglio, Steven P.
通讯作者：
Broglio, Steven P.
DOI：
10.1016/j.dadm.2016.11.003
发表时间：
2017
期刊：
Alzheimer's & dementia (Amsterdam, Netherlands)
影响因子：
--
作者：
Alosco ML;Tripodis Y;Jarnagin J;Baugh CM;Martin B;Chaisson CE;Estochen N;Song L;Cantu RC;Jeromin A;Stern RA
通讯作者：
Stern RA