PUG-SOAP and PUG-REST: web services for programmatic access to chemical information in PubChem.
PUG-SOAP and PUG-REST: web services for programmatic access to chemical information in PubChem.
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DOI：
10.1093/nar/gkv396
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发表时间：
2015-07-01
影响因子：
14.9
通讯作者：
Bryant SH
中科院分区：
文献类型：
--
作者：
Kim S;Thiessen PA;Bolton EE;Bryant SH
PubChem（http：pubchem.ncbi.nlm.nih.gov）是一个关于化学物质及其生物活性的公共信息库，由美国国立卫生研究院（NIH）开发和维护。PubChem包含超过1.8亿个由保藏者提供的化学物质描述，6000万个独特的化学结构和2.25亿个生物活性测定结果，涵盖9000多个独特的蛋白质靶序列。作为化学生物学研究界的一个信息资源，它每天例行收到来自估计每月超过100万个独立用户的100多万个请求。对大量数据的编程访问由几个不同的系统提供，包括美国国家生物技术信息中心（NCBI）的E-Utilities（E-Utilities或E-Utils）和PubChem Power User Gateway（PUG）-通过扩展标记语言（XML）交换数据的通用网关接口（CGI）。PubChem进一步简化了编程访问，提供了两个额外的通用Web服务：PUG-SOAP，它使用简单对象访问协议（SOAP）和PUG-REST，这是一个表述性状态传输（REST）风格的接口。这些接口可以结合使用，以访问PubChem中包含的数据，PubChem与NCBI P2P系统中的30多个数据库集成。
PubChem (http://pubchem.ncbi.nlm.nih.gov) is a public repository for information on chemical substances and their biological activities, developed and maintained by the US National Institutes of Health (NIH). PubChem contains more than 180 million depositor-provided chemical substance descriptions, 60 million unique chemical structures and 225 million bioactivity assay results, covering more than 9000 unique protein target sequences. As an information resource for the chemical biology research community, it routinely receives more than 1 million requests per day from an estimated more than 1 million unique users per month. Programmatic access to this vast amount of data is provided by several different systems, including the US National Center for Biotechnology Information (NCBI)'s Entrez Utilities (E-Utilities or E-Utils) and the PubChem Power User Gateway (PUG)—a common gateway interface (CGI) that exchanges data through eXtended Markup Language (XML). Further simplifying programmatic access, PubChem provides two additional general purpose web services: PUG-SOAP, which uses the simple object access protocol (SOAP) and PUG-REST, which is a Representational State Transfer (REST)-style interface. These interfaces can be harnessed in combination to access the data contained in PubChem, which is integrated with the more than thirty databases available within the NCBI Entrez system.
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影响因子：
14.9
作者：
NCBI Resource Coordinators
通讯作者：
NCBI Resource Coordinators
DOI：
10.1021/ci00057a005
发表时间：
1988-02-01
期刊：
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES
影响因子：
--
作者：
WEININGER, D
通讯作者：
WEININGER, D
影响因子：
8.6
作者：
Heller S;McNaught A;Stein S;Tchekhovskoi D;Pletnev I
通讯作者：
Pletnev I
影响因子：
11.4
作者：
McEntyre, J
通讯作者：
McEntyre, J
影响因子：
14.9
作者：
Wang Y;Xiao J;Suzek TO;Zhang J;Wang J;Bryant SH
通讯作者：
Bryant SH