The impact of fetal growth restriction in diagnosing preeclampsia on the severity of maternal features
The impact of fetal growth restriction in diagnosing preeclampsia on the severity of maternal features
复制标题
诊断先兆子痫时胎儿生长受限对母体特征严重程度的影响
DOI：
10.1111/jog.15152
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发表时间：
2022
影响因子：
1.6
通讯作者：
Osuga Yutaka
中科院分区：
文献类型：
--
作者：
Kasuya Minori;Akiba Naoya;Iriyama Takayuki;Sayama Seisuke;Kubota Kaori;Toshimitsu Masatake;Seyama Takahiro;Sone Kenbun;Kumasawa Keiichi;Nagamatsu Takeshi;Fujii Tomoyuki;Osuga Yutaka
目的我们旨在通过将胎儿生长受限（FGR）作为先兆子痫（PE）的诊断标准与母体器官功能障碍的其他诊断标准进行比较，评估其对母体先兆子痫特征严重程度的影响。方法我们对单胎妊娠进行了回顾性队列研究。根据诊断时的情况，对先有FGR但无母体器官功能障碍的PE病例（F组；n= 28例）和先有母体器官功能障碍但无FGR的PE病例（M组；n= 87例）进行分析。结果F组PE诊断较早（32.5±4.9周比36.7±3.5周，p<0.01）和分娩（33.7±4.5 周 vs. 37.5±3.1 周，p<0.01）。两组之间的孕产妇发病率没有显着差异，包括严重高血压（75.0 vs. 60.0%）、静脉抗高血压药物需求（42.9 vs. 48.3%）或硫酸镁（60.7 vs. 60.7%）。 54.5%），或主要产妇并发症的综合（17.9 vs. 21.8%）。当仅限于妊娠 34 周前诊断出的早发性 PE 时（F 组和 M 组分别为 17 例和 17 例），孕产妇发病率（严重高血压：70.6 比 52.9%，静脉抗高血压药物：35.3 比 35.3%，硫酸镁：58.8 比 47.1%，主要并发症：29.4 比 47.4%） 23.5%）以及从诊断到分娩的持续时间（11.2±14.7天与16.5±21.7天）在两组之间具有可比性。结论我们的结果表明，PE诊断中FGR的存在与诊断时严重孕产妇症状的发展相关，与诊断时母体器官功能障碍的相关性一样，将FGR纳入PE诊断标准可能是合理的。
AimWe aimed to assess the impact of fetal growth restriction (FGR) as a diagnostic criterion for preeclampsia (PE) on the severity of maternal preeclamptic features by comparing it with other diagnostic criteria for PE, maternal organ dysfunction.MethodsWe performed a retrospective cohort study of singleton pregnancies. Based on the status at diagnosis, PE cases preceded by FGR without maternal organ dysfunction (Group F;n= 28) and those preceded by maternal organ dysfunction without FGR (Group M;n= 87) were analyzed.ResultsGroup F had an earlier PE diagnosis (32.5 ± 4.9 vs. 36.7 ± 3.5 weeks,p< 0.01) and delivery (33.7 ± 4.5 vs. 37.5 ± 3.1 weeks,p< 0.01) than Group M. No significant differences in maternal morbidities were observed between the groups, including severe hypertension (75.0 vs. 60.0%), need for intravenous antihypertensives (42.9 vs. 48.3%) or magnesium sulfate (60.7 vs. 54.5%), or a composite of major maternal complications (17.9 vs. 21.8%). When limited to early‐onset PE diagnosed before 34 weeks of gestation (17 and 17 cases in Group F and M, respectively), the frequencies of maternal morbidities (severe hypertension: 70.6 vs. 52.9%, intravenous antihypertensives: 35.3 vs. 35.3%, magnesium sulfate: 58.8 vs. 47.1%, major complications: 29.4 vs. 23.5%) and the duration from diagnosis until delivery (11.2 ± 14.7 vs. 16.5 ± 21.7 days) were comparable between two groups.ConclusionsOur results suggest that the presence of FGR on PE diagnosis is associated with the development of severe maternal symptoms as much as that of maternal organ dysfunction at diagnosis, and it may be reasonable to include FGR in PE diagnostic criteria.
影响因子：
120.7
作者：
Velicer, CM;Heckbert, SR;Taplin, SH
通讯作者：
Taplin, SH