Mapping main, epistatic and sex-specific QTL for body composition in a chicken population divergently selected for low or high growth rate.
Mapping main, epistatic and sex-specific QTL for body composition in a chicken population divergently selected for low or high growth rate.
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DOI：
10.1186/1471-2164-11-107
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发表时间：
2010-02-11
期刊：
影响因子：
4.4
通讯作者：
Aggrey SE
中科院分区：
文献类型：
--
作者：
Ankra-Badu GA;Shriner D;Le Bihan-Duval E;Mignon-Grasteau S;Pitel F;Beaumont C;Duclos MJ;Simon J;Porter TE;Vignal A;Cogburn LA;Allison DB;Yi N;Aggrey SE
阐明人体成分的遗传基础对农业和医学都很重要。此外，在统计模型中纳入了基因-基因交互作用，进一步深入了解了构成身体成分特征的遗传因素。我们利用贝叶斯模型选择，对两个不同生长速度选择的鸡品系F2正反交的主效、上位性和性别特异性QTL进行了全面的定位。我们在13条染色体上定位了17个主效QTL，以及几个性别特异和性别拮抗的QTL，分别控制胸肉产量、大腿+鸡腿产量和腹脂。在胸大肌和胸小肌中都发现了不同的QTL，这表明它们可能受到不同的调控机制的控制。性别与QTL的显著交互作用使得能够检测到身体成分和腹部脂肪的性别特异和性别拮抗的QTL。我们发现了几个雌性特有的大白杨QTL和性别拮抗的小白杨和腹肥QTL。此外，不同染色体上的几个QTL相互作用，影响身体成分和腹部脂肪。主效、上位性和性别二态QTL的检测表明，体细胞生长的遗传调控是复杂的。对这种调控机制的了解是定位控制禽类模型体细胞生长的QTL所依据的特定基因的关键。
Delineating the genetic basis of body composition is important to agriculture and medicine. In addition, the incorporation of gene-gene interactions in the statistical model provides further insight into the genetic factors that underlie body composition traits. We used Bayesian model selection to comprehensively map main, epistatic and sex-specific QTL in an F2 reciprocal intercross between two chicken lines divergently selected for high or low growth rate. We identified 17 QTL with main effects across 13 chromosomes and several sex-specific and sex-antagonistic QTL for breast meat yield, thigh + drumstick yield and abdominal fatness. Different sets of QTL were found for both breast muscles [Pectoralis (P) major and P. minor], which suggests that they could be controlled by different regulatory mechanisms. Significant interactions of QTL by sex allowed detection of sex-specific and sex-antagonistic QTL for body composition and abdominal fat. We found several female-specific P. major QTL and sex-antagonistic P. minor and abdominal fatness QTL. Also, several QTL on different chromosomes interact with each other to affect body composition and abdominal fatness. The detection of main effects, epistasis and sex-dimorphic QTL suggest complex genetic regulation of somatic growth. An understanding of such regulatory mechanisms is key to mapping specific genes that underlie QTL controlling somatic growth in an avian model.
影响因子：
4.1
作者：
Abasht, B;Pittel, F;Douaire, M
通讯作者：
Douaire, M