YLoc--an interpretable web server for predicting subcellular localization.

YLoc--an interpretable web server for predicting subcellular localization.
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DOI:
10.1093/nar/gkq477
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发表时间:
2010-07
影响因子:
14.9
通讯作者:
Kohlbacher O
Kohlbacher O
中科院分区:
生物学2区
文献类型:
--
作者:
Briesemeister S;Rahnenführer J;Kohlbacher O

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预测亚细胞定位已成为一个有价值的替代费时的实验方法。许多这些预测的主要缺点是它们缺乏可解释性,以及它们不提供对单个预测的置信度的估计。我们提出YLoc,一个可解释的网络服务器,用于预测亚细胞定位。YLoc使用自然语言来解释为什么做出预测,以及蛋白质的生物学特性主要负责它。此外,YLoc估计自己预测的可靠性。因此,YLoc可以帮助理解蛋白质定位和蛋白质的定位工程。YLoc网络服务器可在www.multiloc.org/YLoc上获得。
Predicting subcellular localization has become a valuable alternative to time-consuming experimental methods. Major drawbacks of many of these predictors is their lack of interpretability and the fact that they do not provide an estimate of the confidence of an individual prediction. We present YLoc, an interpretable web server for predicting subcellular localization. YLoc uses natural language to explain why a prediction was made and which biological property of the protein was mainly responsible for it. In addition, YLoc estimates the reliability of its own predictions. YLoc can, thus, assist in understanding protein localization and in location engineering of proteins. The YLoc web server is available online at www.multiloc.org/YLoc.
DOI: 10.1186/1471-2105-10-274
发表时间: 2009-09-01
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