Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill
Sequence of a novel simian immunodeficiency virus from a wild-caught African mandrill
复制标题
来自野生捕获的非洲山魈的新型猿猴免疫缺陷病毒的序列
作者：
H. Tsujimoto;A. Hasegawa;N. Maki;M. Fukasawa;T. Miura;Stephan Speidel;R. Cooper;E. Moriyama;T. Gojobori;M. Hayami
自从从圈养猕猴中分离出 HIV-2 相关病毒 (SIVMAC)1,2 以来，人类免疫缺陷病毒的起源这一备受争议的话题 3-9 已被归因于猴子 3,4。 SIVAGM 的序列源自自然感染的非洲绿猴，显示出与 HIV-1 和 HIV-2 相同的相关性，表明这些病毒不太可能源自 SIVAGM。然而，最近对圈养乌白眉猴 (SIVSM) 的 SIV 进行的序列分析表明，其与 HIV-2 和 SIVMAC 密切相关，表明 HIV-2 和 SIVMAC 可能起源于 SIVSM（参考文献 4、7、9）。我们在这里报告了一种新型猿猴慢病毒 SIVMND 的序列，该病毒是从非洲野生捕获的山魈中分离出来的。它与其他三个主要类群 HIV-1、HIV-2/SIVMAC/SIVSM 和 SIVAGM 不同，因此代表灵长类慢病毒的第四个主要类群。系统发育分析表明，这四个主要病毒群可能在大约同一时间从共同祖先中分离出来，远早于艾滋病在人类中的传播。
SINCE the isolation of an HIV-2-related virus from captive macaques (SIVMAC)1,2, the origin of human immunodeficiency viruses, a much debated subject3–9, has been attributed to monkeys3,4. The sequence of SIVAGM, which is derived from a naturally infected African green monkey, shows equal relatedness to HIV-1 and HIV-2, suggesting that the derivation of these viruses from SIVAGM is unlikely. Recent sequence analysis of SIV from a captive sooty mangabey (SIVSM), however, shows its close relatedness to HIV-2 and SIVMAC, indicating a possible origin of HIV-2 and SIVMAC from SIVSM (refs 4, 7, 9). We report here the sequence of a novel simian lentivirus, SIVMND, isolated from a wild-caught mandrill in Africa10. It is distinct from the three other main groups, HIV-1, HIV-2/SIVMAC/SIVSM and SIVAGM, and therefore represents a fourth main group of primate lentiviruses. Phylogenetic analysis indicates that these four main virus groups might have diverged from a common ancestor at about the same time, long before the spread of AIDS in humans.
影响因子：
56.9
作者：
FRANKEL, AD;BREDT, DS;PABO, CO
通讯作者：
PABO, CO
影响因子：
10.7
作者：
S. Yokoyama;L. Chung;T. Gojobori
通讯作者：
S. Yokoyama;L. Chung;T. Gojobori
影响因子：
10.7
作者：
Wenhao Li;M. Tanimura;P. Sharp
通讯作者：
Wenhao Li;M. Tanimura;P. Sharp