Toxic emissions resulting from sucralose added to electronic cigarette liquids.
Toxic emissions resulting from sucralose added to electronic cigarette liquids.
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DOI：
10.1080/02786826.2019.1645294
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发表时间：
2019
影响因子：
5.2
通讯作者：
Saliba, Najat Aoun
中科院分区：
文献类型：
--
作者：
El-Hage, Rachel;El-Hellani, Ahmad;Haddad, Christina;Salman, Rola;Talih, Soha;Shihadeh, Alan;Eissenberg, Thomas;Saliba, Najat Aoun
关键词：
电子烟(ECIG)之所以吸引人，部分原因是电子烟中使用的液体具有多种口味。有人担心，一些ECIG液体口味，特别是那些甜的，正在吸引原本尼古丁天真的年轻人加入ECIG。三氯蔗糖是一种人工的无热量甜味剂，添加到一些ECIG液体中。在这项研究中，我们评估了含有三氯蔗糖的ECIG液体被雾化时可能产生的毒物，即氯丙醇的异构体。建立了固相萃取分离丙二醇甘油基质中氯丙醇的分析方法。氯丙醇经过硅烷化反应后，在GC-MS上进行分析。通过改变ECIG装置的设计和功率输出以及液体中三氯蔗糖的浓度，研究了不同的ECIG操作条件对氯丙醇生成的影响。加热的含三氯蔗糖的ECIG液体会产生两种有毒化合物，可以在由此产生的气雾剂中找到。3-氯丙醇(3-MCPD)和1，3-二氯丙醇(1，3-DCP)在所有条件下均与液体三氯蔗糖含量显著相关。对ECIG的有效监管将最大限度地减少使用者和旁观者对这些和其他ECIG毒物的暴露。
Electronic cigarettes (ECIGs) are appealing in part because of the many flavors of the liquids used in them. Concerns have been raised that some ECIG liquid flavors, especially those that are sweet, are attracting otherwise nicotine-naïve youth to ECIGs. Sucralose is an artificial, non-caloric sweetener that is added to some ECIG liquids. In this study, we evaluated the toxicants, namely isomers of chloropropanols that can be produced when sucralose-containing ECIG liquid is aerosolized. An analytical separation method relying on solid-phase extraction (SPE) to isolate chloropropanols from the propylene glycol/glycerol matrix was developed. Chloropropanols were then derivatized by silylation before they were analyzed on GC-MS. The influence of different ECIG operating conditions on the generation of chloropropanols was studied by varying ECIG device design and power output and also the sucralose concentration of the liquid. Heated sucralose-containing ECIG liquids produce two toxic compounds that can be found in the resulting aerosols. The two chloropropanols, 3-monochloro-1,2-propanediol (3-MCPD) and 1,3-dichloropropanol (1,3-DCP) that were detected under all conditions were found to be correlated significantly with liquid sucralose content. Effective regulation of ECIGs will minimize user and bystander exposure to these and other ECIG toxicants.
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DOI：
10.3390/ijerph111111192
发表时间：
2014-10-28
影响因子：
--
作者：
Bekki K;Uchiyama S;Ohta K;Inaba Y;Nakagome H;Kunugita N
通讯作者：
Kunugita N
影响因子：
6
作者：
Dong, Shujun;Wu, Jiajia;Zheng, Minghui
通讯作者：
Zheng, Minghui
影响因子：
4.3
作者：
Cho, Wan-Seob;Han, Beorn Seok;Jang, Dong Deuk
通讯作者：
Jang, Dong Deuk
影响因子：
4.6
作者：
de Oliveira DN;de Menezes M;Catharino RR
通讯作者：
Catharino RR
DOI：
10.1080/01635581.2016.1224366
发表时间：
2016-11
期刊：
Nutrition and cancer
影响因子：
--
作者：
Berry C;Brusick D;Cohen SM;Hardisty JF;Grotz VL;Williams GM
通讯作者：
Williams GM