Probing long-range anisotropic interactions - A general and sign-sensitive strategy to measure 1H-1H residual dipolar couplings as a key advance for organic structure determination.
Probing long-range anisotropic interactions - A general and sign-sensitive strategy to measure 1H-1H residual dipolar couplings as a key advance for organic structure determination.
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探测长程各向异性相互作用 - 测量 1H-1H 残余偶极耦合的通用且符号敏感的策略是有机结构测定的关键进展
DOI：
10.1002/anie.201915278
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发表时间：
2020
影响因子：
--
通讯作者：
B. Luy
中科院分区：
文献类型：
--
作者：
D. Sinnaeve;J. Ilgen;M. E. Di Pietro;J. Primozic;V. Schmidts;C. M. Thiele;B. Luy
残留偶极耦合(RDC)是解析有机结构的最有效的核磁共振参数之一。为了在柔性化合物等日益复杂的情况下最大限度地发挥其有效性，需要在原子核之间进行最大限度的RDC采样，包括符号信息在内的大量取向分布。为此，容易获得的单键1H-13C RDC本身往往达不到要求。长距离的1H-1H RDC既丰富又典型地采样高度互补的取向，但由于1H-1H耦合的溢出，以符号敏感的方式访问它们已经严重受阻。在这里，我们提出了一种普遍适用的策略，它允许测量大量的1H-1H RDC，包括它们的符号，它基于改进的迷幻方法和新的选择性恒定时间β-COSY实验的组合。证明了1H-1H RDC在更好地确定分子排列和区分对映异构体和非对映异构体方面的潜力。
Residual dipolar couplings (RDCs) are amongst the most powerful NMR parameters for organic structure elucidation. In order to maximize their effectiveness in increasingly complex cases such as flexible compounds, a maximum of RDCs between nuclei sampling a large distribution of orientations is needed, including sign information. For this, the easily accessible one‐bond1H–13C RDCs alone often fall short. Long‐range1H–1H RDCs are both abundant and typically sample highly complementary orientations, but accessing them in a sign‐sensitive way has been severely obstructed due to the overflow of1H–1H couplings. Here, we present a generally applicable strategy that allows the measurement of a large number of1H–1H RDCs, including their signs, which is based on a combination of an improved PSYCHEDELIC method and a new selective constant‐timeβ‐COSY experiment. The potential of1H–1H RDCs to better determine molecular alignment and to discriminate between enantiomers and diastereomers is demonstrated.
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影响因子：
16.6
作者：
Foroozandeh, Mohammadali;Adams, Ralph W.;Meharry, Nicola J.;Jeannerat, Damien;Nilsson, Mathias;Morris, Gareth A.
通讯作者：
Morris, Gareth A.
影响因子：
2.2
作者：
Zhengrong Wu;A. Bax
通讯作者：
Zhengrong Wu;A. Bax
耦合网络片段拓扑过滤的选择性二维核磁共振实验
DOI：
--
发表时间：
1991
期刊：
影响因子：
--
作者：
L. Emsley;G. Bodenhausen
通讯作者：
G. Bodenhausen
影响因子：
16.6
作者：
Nath, Nilamoni;d'Auvergne, Edward J.;Griesinger, Christian
通讯作者：
Griesinger, Christian
影响因子：
16.6
作者：
Boettcher, Benjamin;Schmidts, Volker;Thiele, Christina M.
通讯作者：
Thiele, Christina M.