Divergence in proportional fat intake in AKR/J and SWR/J mice endures across diet paradigms.

Divergence in proportional fat intake in AKR/J and SWR/J mice endures across diet paradigms.
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AKR/J 和 SWR/J 小鼠脂肪摄入比例的差异在不同饮食模式中持续存在。

DOI:
10.1152/ajpregu.1999.277.3.r776
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发表时间:
1999
期刊:
The American journal of physiology
影响因子:
--
通讯作者:
West,DB
West,DB
中科院分区:
--
文献类型:
--
作者:
Smith,BK;Andrews,PK;York,DA;West,DB

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这些实验旨在检验以下假设:之前在 AKR/J(脂肪偏好)和 SWR/J(碳水化合物偏好)小鼠中描述的大量营养素选择的对比模式并不依赖于单一饮食模式。通过提供具有多种物理、感官和营养特性的两种选择饮食,在幼稚小鼠中测试了小鼠品系对脂肪摄入比例的影响。在三个独立的实验中,AKR/J 小鼠比 SWR/J 小鼠优先选择并消耗更高比例的高脂肪饮食能量。具体来说,这种表型差异是在 1) 脂肪-蛋白质与碳水化合物-蛋白质饮食中观察到的,与脂肪类型(植物起酥油或猪油)无关,2) 等热量、高脂与低脂液体饮食制剂,以及 3) 高脂与低脂粉状颗粒饮食。这些结果证实了我们之前的观察结果,即与使用三种常量营养素选择饮食的 SWR/J 小鼠相比,AKR/J 小鼠的脂肪摄入比例更高,并表明这种菌株差异普遍存在于几种饮食模式中。这种品系差异很大程度上归因于 AKR/J 小鼠强大且可靠的脂肪偏好。相比之下,SWR/J 小鼠对常量营养素的偏好因范式而异,表明该品系对某些口腔感觉或食后因素的反应不同。
These experiments were designed to test the hypothesis that the contrasting patterns of macronutrient selection described previously in AKR/J (fat preference) and SWR/J (carbohydrate preference) mice are not dependent on a single diet paradigm. The effect of mouse strain on proportional fat intake was tested in naive mice by presenting two-choice diets possessing a variety of physical, sensory, and nutritive properties. In three separate experiments, AKR/J mice preferentially selected and consumed a higher proportion of energy from the high-fat diet than SWR/J mice. Specifically, this phenotypic difference was observed with1) fat-protein vs. carbohydrate-protein diets, independent of fat type (vegetable shortening or lard),2) isocaloric, high- vs. low-fat liquid diet preparations, and3) high- vs. low-fat powdered-granular diets. These results confirm our previous observation of a higher proportional fat intake by AKR/J compared with SWR/J mice using the three-choice macronutrient selection diet and show that this strain difference generalizes across several diet paradigms. This strain difference is due largely to the robust and reliable fat preference of the AKR/J mice. In contrast, macronutrient preference in SWR/J mice varied across paradigms, suggesting a differential response by this strain to some orosensory or postingestive factor(s).
根据热量密度调节口味偏好。
DOI: 10.1037//0097-7403.7.1.59
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