Linking late life depression and Alzheimer's disease: mechanisms and resilience.
Linking late life depression and Alzheimer's disease: mechanisms and resilience.
复制标题
DOI：
10.1007/s40473-019-00180-7
复制
发表时间：
2019
影响因子：
1.7
通讯作者：
Koppelmans V
中科院分区：
文献类型：
--
作者：
Weisenbach SL;Kim J;Hammers D;Konopacki K;Koppelmans V
本文综述了阿尔茨海默病(AD)和老年抑郁症(LLD)的最新文献。它描述了与这两种疾病相关的共同神经生物学特征，以及可能增加对认知功能下降和AD的发病和严重程度的复原力的因素。最后，我们提出了一些未来的研究方向，以改进对这两种疾病的检测、管理和治疗，流行病学研究一直表明LLD和AD之间存在显著的关系，支持抑郁是AD的先兆特征，是AD的风险因素，并观察到两种疾病过程中的一些共同风险因素。LLD和AD共有的三个主要神经生物学特征包括神经变性、脑血管功能障碍和神经炎症水平增加。还有一些潜在的可改变的因素可以增加对AD和LLD的复原力，包括社会支持、身体和认知参与以及认知储备。我们认为，在抑郁症的背景下，神经退行性变、脑血管疾病和神经炎症等神经生物学事件导致大脑更容易受到阿尔茨海默病的病理生理特征的影响，从而降低了阿尔茨海默病行为表现(即认知功能减退和痴呆)的开始门槛。我们讨论了可以提高对AD和LLD的复原力的因素，包括社会支持、身体和认知投入以及认知储备。最后，我们对未来的研究方向进行了讨论。
This review summarizes recent literature linking Alzheimer’s disease (AD) and late life depression (LLD). It describes shared neurobiological features associated with both conditions, as well as factors that may increase resilience to onset and severity of cognitive decline and AD. Finally, we pose a number of future research directions toward improving detection, management, and treatment of both conditions Epidemiological studies have consistently shown a significant relationship between LLD and AD, with support for depression as a prodromal feature of AD, a risk factor for AD, and observation of some shared risk factors underlying both disease processes. Three major neurobiological features shared by LLD and AD include neurodegeneration, disruption to cerebrovascular functioning, and increased levels of neuroinflammation. There are also potentially modifiable factors that can increase resilience to AD and LLD, including social support, physical and cognitive engagement, and cognitive reserve. We propose that, in the context of depression, neurobiological events, such as neurodegeneration, cerebrovascular disease, and neuroinflammation result in a brain that is more vulnerable to the consequences of the pathophysiological features of AD, lowering the threshold for the onset of the behavioral presentation of AD (i.e., cognitive decline and dementia). We discuss factors that can increase resilience to AD and LLD, including social support, physical and cognitive engagement, and cognitive reserve. We conclude with a discussion of future research directions.
登录
查看更多内容
影响因子：
168.9
作者：
Fratiglioni, L;Wang, HX;Winblad, B
通讯作者：
Winblad, B
DOI：
10.1073/pnas.1107411108
发表时间：
2011-09-06
影响因子：
11.1
作者：
Cirrito, John R.;Disabato, Brianne M.;Sheline, Yvette I.
通讯作者：
Sheline, Yvette I.
影响因子：
5.3
作者：
Gandelman, Jason A.;Kang, Hakmook;Taylor, Warren D.
通讯作者：
Taylor, Warren D.
影响因子：
5.8
作者：
Arbus, C.;Gardette, V.;Vellas, B.
通讯作者：
Vellas, B.
影响因子：
3.7
作者：
Benyamini, Y;Lomranz, J
通讯作者：
Lomranz, J