Adenosinergic Signaling in Liver Fibrosis
Adenosinergic Signaling in Liver Fibrosis
复制标题
肝纤维化中的腺苷信号传导
DOI：
10.1002/cld.777
复制
发表时间：
2019
影响因子：
--
通讯作者：
Jiang ZG
中科院分区：
文献类型：
--
作者：
Tiwari‐Heckler S;Jiang ZG
肝纤维化是各种慢性肝病导致肝功能衰竭及相关并发症的共同途径。该过程的特征在于过度和功能失调的伤口愈合反应，可导致慢性组织损伤，伴随细胞外基质的过度沉积。肝纤维化是由肝细胞和非肝细胞之间的协同相互作用介导的，这一点已经变得很明显。目前，这些途径中有几种被用于药物开发。尽管目前缺乏美国食品和药物管理局批准的针对肝纤维化的治疗方法，但越来越多的证据表明，喝咖啡与肝纤维化的风险降低有关。由于咖啡因是腺苷拮抗剂，这提高了肝纤维化中腺苷能信号的相关性。
Liver fibrosis is the common pathway shared by various chronic liver diseases leading to liver failure and related complications. This process, characterized by an exaggerated and dysfunctional wound-healing response, can result in a chronic tissue injury with an excessive deposition of extracellular matrix. It has become evident that fibrosis in the liver is mediated by concerted interplays between hepatic and nonhepatic cells. Several of these pathways are currently exploited for drug development. Despite the lack of US Food and Drug Administration–approved therapeutics that targets fibrogenesis at present, accumulating evidence indicates that drinking coffee is associated with a lower risk for liver fibrosis. Because caffeine is an adenosine antagonist, this raised the relevance of adenosinergic signaling in liver fibrosis.
DOI：
10.3109/00365518609086483
发表时间：
1986-02-01
影响因子：
2.1
作者：
ARNESEN, E;HUSEBY, NE;TRY, K
通讯作者：
TRY, K