Hollow mesoporous carbon@Pt Janus nanomotors with dual response of H2O2 and near-infrared light for active cargo delivery
Hollow mesoporous carbon@Pt Janus nanomotors with dual response of H2O2 and near-infrared light for active cargo delivery
复制标题
中空介孔碳@Pt Janus纳米电机具有H2O2和近红外光双重响应，用于主动货物输送
DOI：
10.1016/j.apmt.2019.07.017
复制
发表时间：
2019-12
影响因子：
8.3
通讯作者：
Xueji Zhang
中科院分区：
文献类型：
--
作者：
Yi Xing;Mengyun Zhou;Xin Du;Xiaoyu Li;Jianqiang Li;Tailin Xu;Xueji Zhang
介孔碳纳米颗粒因其优异的物理化学性质而被广泛用于构建纳米治疗诊断系统。在此，我们引入这些介孔纳米粒子作为纳米载体，以建立自推进运输系统。这种纳米载体通过将Pt NP沉积到半球表面上而成功地制造。与传统的二氧化硅基纳米马达相比，基于中空介孔碳纳米球（HMCNs）的纳米马达由于其疏水性质可以实现抗癌药物盐酸阿霉素（DOX）的高负载效率（1370 mg/g）。通过引入近红外光照射观察到增强的运动，这是由于HMCNs的局部热泳作用引起的，并且通过引入H2 O2也观察到增强的运动，HMCNs@Pt通过不对称分解驱动。有趣的是，这种增强的运动还导致粘附在活癌细胞表面的HMCNs的量增加，这有利于提高药物递送的效率。这种具有高货物装载能力和双驱动自主运动能力的协同碳基运输系统显示出进一步功能化的“智能”设备的巨大潜力。
Mesoporous carbon nanoparticles (NPs) are widely used to construct nano-theranostic systems due to their excellent physicochemical properties. Herein, we introduce these mesoporous NPs as nanocarriers to build self-propelled transport systems. Such nanocarriers are successfully fabricated by depositing Pt NPs onto the half-sphere surface. Compared with conventional silica-based nanomotors, hollow mesoporous carbon nanospheres (HMCNs) based nanomotors can achieve a high loading efficiency (1370 mg/g) of anticancer drug doxorubicin hydrochloride (DOX) due to its hydrophobic nature. The enhanced motion is observed by introducing the NIR-light irradiation due to the local thermophoresis from the upward temperature of HMCNs and also observed by introducing H2O2that drives the HMCNs@Pt by the asymmetric decomposition. Interestingly, such enhanced motion also results in the increase of the amount of HMCNs adhering to the surface of living cancer cells, which is beneficial for enhancing the efficiency of drug delivery. This synergetic carbon-based transport system with high cargo loading capacity and dual actuated autonomous motion ability displays immense potential for further functional “smart” devices.
登录
查看更多内容
影响因子：
--
作者：
Min Zhang;Hao Song;Yannan Yang;Xiaodan Huang;Yang Liu;Chao Liu;Chengzhong Yu
通讯作者：
Min Zhang;Hao Song;Yannan Yang;Xiaodan Huang;Yang Liu;Chao Liu;Chengzhong Yu
影响因子：
16.6
作者：
Sanchez, Samuel;Soler, Lluis;Katuri, Jaideep
通讯作者：
Katuri, Jaideep
用于药物封装和输送的直径低于 100 nm 的自驱动 Janus 介孔二氧化硅纳米电机
影响因子：
2.9
作者：
Xuan, Mingjun;Shao, Jingxin;He, Qiang
通讯作者：
He, Qiang
影响因子：
17.1
作者：
Guix, Maria;Orozco, Jahir;Wang, Joseph
通讯作者：
Wang, Joseph
影响因子：
--
作者：
M. Burghard
通讯作者：
M. Burghard