Ambient Air Pollution and Atherosclerosis: Recent Updates.
Ambient Air Pollution and Atherosclerosis: Recent Updates.
复制标题
环境空气污染与动脉粥样硬化：最新进展。
DOI：
10.1007/s11883-021-00958-9
复制
发表时间：
2021-08-21
影响因子：
5.8
通讯作者：
Rajagopalan S
中科院分区：
文献类型：
--
作者：
Bevan GH;Al-Kindi SG;Brook R;Rajagopalan S
During the past century, exposure to particulate matter (PM) air pollution < 2.5 μm in diameter (PM2.5) has emerged as an all-pervading element of modern-day society. This increased exposure has come at the cost of heightened risk for cardiovascular (CV) morbidity and mortality. Not only can short-term PM2.5 exposure trigger acute CV events in susceptible individuals, but longer-term exposure over years augments CV risk to a greater extent in comparison with short-term exposure. The purpose of this review is to examine the available evidence for how ambient air pollution exposure may precipitate events at various time frames. Recent epidemiological studies have demonstrated an association between ambient PM2.5 exposure and the presence and progression of atherosclerosis in humans. Multiple animal exposure experiments over two decades have provided strong corroborative evidence that chronic exposure in fact does enhance the progression and perhaps vulnerability characteristics of atherosclerotic lesions. Evidence from epidemiological studies including surrogates of atherosclerosis, human translational studies, and mechanistic investigations utilizing animal studies have improved our understanding of how ambient air pollution may potentiate atherosclerosis and precipitate cardiovascular events. Even so, future research is needed to fully understand the contribution of different constituents in ambient air pollution–mediated atherosclerosis as well as how other systems may modulate the impact of exposure including adaptive immunity and the gut microbiome. Nevertheless, due to the billions of people continually exposed to PM2.5, the long-term pro-atherosclerotic effects of this ubiquitous air pollutant are likely to be of enormous and growing global public health importance. The online version contains supplementary material available at 10.1007/s11883-021-00958-9.
登录
查看更多内容
超铁颗粒在空气颗粒质量与心血管健康之间关联中的潜在作用。
影响因子：
10.4
作者：
Delfino RJ;Sioutas C;Malik S
通讯作者：
Malik S
影响因子：
2.1
作者：
Chen LC;Quan C;Hwang JS;Jin X;Li Q;Zhong M;Rajagopalan S;Sun Q
通讯作者：
Sun Q
影响因子：
10.4
作者：
Haberzettl P;Lee J;Duggineni D;McCracken J;Bolanowski D;O'Toole TE;Bhatnagar A;Conklin DJ
通讯作者：
Conklin DJ
影响因子：
10.4
作者：
Bell ML;Ebisu K
通讯作者：
Ebisu K
影响因子：
24
作者：
Liang, Fengchao;Liu, Fangchao;Gu, Dongfeng
通讯作者：
Gu, Dongfeng