High levels of plasma IL‐10 and expression of IL‐10 by keratinocytes during visceral leishmaniasis predict subsequent development of post‐kala‐azar dermal leishmaniasis
High levels of plasma IL‐10 and expression of IL‐10 by keratinocytes during visceral leishmaniasis predict subsequent development of post‐kala‐azar dermal leishmaniasis
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内脏利什曼病期间血浆 IL-10 水平高以及角质形成细胞表达 IL-10 可预测黑热病后皮肤利什曼病的后续发展
DOI：
10.1046/j.1365-2249.1998.00468.x
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发表时间：
1998
影响因子：
4.6
通讯作者：
T. Theander
中科院分区：
文献类型：
--
作者：
S. Gasim;A. Elhassan;Eltahir A. G. Khalil;A. Ismail;A. M. Kadaru;A. Kharazmi;T. Theander
一些患者在接受了全身感染（内脏利什曼病）治疗后，出现了黑热病后皮肤利什曼病（PKDL）。为什么寄生虫会在病人成功治疗全身性疾病后引起皮肤症状，这一直是个谜。我们在此报道，在内脏利什曼病治疗前可以预测PKDL的发展，并且IL - 10参与了发病机制。在内脏利什曼病治疗前，利什曼原虫存在于皮肤中，所有患者的皮肤看起来都很正常。然而，IL - 10在所有后来发展为PKDL的患者（1组）的角化细胞和/或汗腺中检测到，而在任何未发展为PKDL的患者（2组）中均未检测到。此外，1组小鼠血浆和外周血单个核细胞培养上清液中IL - 10的水平高于2组。
Some patients develop post‐kala‐azar dermal leishmaniasis (PKDL) after they have been treated for the systemic infection kala‐azar (visceral leishmaniasis). It has been an enigma why the parasites cause skin symptoms after the patients have been successfully treated for the systemic disease. We report here that PKDL development can be predicted before treatment of visceral leishmaniasis, and that IL‐10 is involved in the pathogenesis. Before treatment of visceral leishmaniasis, Leishmania parasites were present in skin which appeared normal on all patients. However, IL‐10 was detected in the keratinocytes and/or sweat glands of all patients who later developed PKDL (group 1) and not in any of the patients who did not develop PKDL (group 2). Furthermore, the levels of IL‐10 in plasma as well as in peripheral blood mononuclear cell culture supernatants were higher in group 1 than in group 2.
影响因子：
15.9
作者：
HOLADAY, BJ;POMPEU, MMD;LOCKSLEY, RM
通讯作者：
LOCKSLEY, RM
实验性利什曼病的成功化疗受到治疗前 T 细胞反应极性的影响。
DOI：
10.1093/infdis/173.4.979
发表时间：
1996
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Nabors,GS;Farrell,JP
通讯作者：
Farrell,JP