Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case-control study.
Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case-control study.
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DOI：
10.1099/vir.0.2008/002824-0
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发表时间：
2008-11
期刊：
影响因子：
--
通讯作者：
Harrison TJ
中科院分区：
文献类型：
--
作者：
Fang ZL;Sabin CA;Dong BQ;Wei SC;Chen QY;Fang KX;Yang JY;Huang J;Wang XY;Harrison TJ
基于中国广西龙安县的一项研究队列，对33对病例和对照组进行了配对巢式病例对照研究，以确定感染具有前s缺失的乙型肝炎病毒（HBV）是否与肝细胞癌（HCC）的发展独立相关，而不存在基础核心启动子（BCP）双突变的混杂影响。在控制BCP双突变的影响下，HCC中pre-S缺失的发生率（45.5%，33人中15人）显著高于对照组（18.2%，33人中6人）（P<0.01）。大多数前s缺失发生或涉及前s2区域的5 '一半，HCC（93.3%, 15 / 14）与对照组（66.7%,6 / 4）在该区域的差异具有统计学意义（P=0.015）。BCP突变组和BCP野生型组pre-S缺失发生率无显著差异（P>0.05），基因型B和基因型C之间pre-S缺失发生率无显著差异（P>0.1）。这些结果表明，pre-S缺失是HCC的独立危险因素，其出现和影响与BCP突变无关。pre-S2的5 '端是缺失突变的有利位点，特别是在HCC病例中。需要进一步的前瞻性研究来证实这些突变在HCC发展中的作用。
A matched nested case–control study of 33 paired cases and controls was conducted, based on a study cohort in Long An county, Guangxi, China, to determine whether infection with hepatitis B virus (HBV) with pre-S deletions is independently associated with the development of hepatocellular carcinoma (HCC), without the confounding effects of basal core promoter (BCP) double mutations. The prevalence of pre-S deletions was significantly higher in HCC (45.5 %, 15 of 33) than the controls (18.2 %, 6 of 33) (P<0.01), under the control of the influence of BCP double mutations. Most of the pre-S deletions occurred in, or involved, the 5′ half of the pre-S2 region and the difference between HCC (93.3 %, 14 of 15) and controls (66.7 %, four of six) was significant for this region (P=0.015). There was no significant difference in pre-S deletions between the BCP mutant group and BCP wild-type group (P>0.05), nor was the prevalence of pre-S deletions significantly different between genotypes B and C (P>0.1). These results suggest that pre-S deletions constitute an independent risk factor for HCC and their emergence and effect are independent of BCP mutations. The 5′ terminus of pre-S2 is the favoured site for the deletion mutations, especially in HCC cases. Further prospective studies are required to confirm the role of these mutations in the development of HCC.
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影响因子：
120.7
作者：
Chen, CJ;Yang, HI;Iloeje, UH
通讯作者：
Iloeje, UH
影响因子：
13.5
作者：
Fan, YF;Lu, CC;Su, IJ
通讯作者：
Su, IJ
DOI：
10.1046/j.1440-1746.2000.02187.x
发表时间：
2000-05-01
影响因子：
4.1
作者：
Fan, YF;Lu, CC;Su, IJ
通讯作者：
Su, IJ
DOI：
10.1111/j.1440-1746.2006.04515.x
发表时间：
2007-07-01
影响因子：
4.1
作者：
Lin, Chih-Lin;Liu, Chen-Hua;Kao, Jia-Horng
通讯作者：
Kao, Jia-Horng
影响因子：
29.4
作者：
Kao, JH;Chen, PJ;Chen, DS
通讯作者：
Chen, DS