Hands-on training in structural biology, a tool for sustainable development in Africa series 4.
Hands-on training in structural biology, a tool for sustainable development in Africa series 4.
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DOI：
10.1242/bio.059487
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发表时间：
2022-08-15
期刊：
影响因子：
2.4
通讯作者：
Nji, Emmanuel
中科院分区：
文献类型：
--
作者：
Ouologuem, Dinkorma T.;Maiga, Fatoumata O.;Dara, Antoine;Djimde, Abdoulaye;Traore, Daouda A. K.;Nji, Emmanuel
结构生物学是理解疾病分子基础的重要工具，它可以指导新药、疫苗的合理设计和现有药物的优化。然而，由于资源有限、缺乏训练有素的人员以及技术熟练的科学家大批离开，大多数非洲国家没有进行结构生物学研究。最紧迫的要求是在非洲新兴中心的基础上再接再厉--一些成熟的中心，另一些正在增长。这可以通过讲习班来实现，这些讲习班改善联网、提高技能并制定机制，以便获得光源光束线，以确定整个大陆的X射线结构。这将鼓励结构生物学的发展，结构生物学是了解生物功能和开发新的抗菌剂和其他药物的核心。有鉴于此，BioStruct-Africa和马里巴马科的疟疾研究和培训中心(MRTC)组织了结构生物学系列4的实践培训讲习班，以帮助弥合这一差距。研讨会于2022年4月25日至28日由MRTC主办。通过一系列讲座和实践，讲习班向与会者介绍了如何利用结构生物学来寻找解决非洲流行疾病的办法。简短的培训让他们概述了目标选择、蛋白质生产和纯化、结构确定技术，以及结合高通量、结构导向、基于片段的药物设计进行分析。摘要：BioStruct-非洲一直在为非洲的生物学家和研究人员建设结构生物学方面的能力。
Structural biology is an essential tool for understanding the molecular basis of diseases, which can guide the rational design of new drugs, vaccines, and the optimisation of existing medicines. However, most African countries do not conduct structural biology research due to limited resources, lack of trained persons, and an exodus of skilled scientists. The most urgent requirement is to build on the emerging centres in Africa – some well-established, others growing. This can be achieved through workshops that improve networking, grow skills, and develop mechanisms for access to light source beamlines for defining X-ray structures across the continent. These would encourage the growth of structural biology, which is central to understanding biological functions and developing new antimicrobials and other drugs. In this light, a hands-on training workshop in structural biology series 4 was organised by BioStruct-Africa and the Malaria Research and Training Center (MRTC) in Bamako, Mali, to help bridge this gap. The workshop was hosted by MRTC from the 25th to 28th of April 2022. Through a series of lectures and practicals, the workshop enlightened the participants on how structural biology can be utilised to find solutions to the prevalent diseases in Africa. The short training gave them an overview of target selection, protein production and purification, structural determination techniques, and analysis in combination with high-throughput, structure-guided, fragment-based drug design. Summary: BioStruct-Africa has been building capacity in structural biology for Africa-based biologists and researchers.
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影响因子：
16.6
作者：
Thulasingam M;Orellana L;Nji E;Ahmad S;Rinaldo-Matthis A;Haeggström JZ
通讯作者：
Haeggström JZ
影响因子：
64.8
作者：
Qureshi, Abdul Aziz;Suades, Albert;Drew, David
通讯作者：
Drew, David
影响因子：
16.8
作者：
Nji，Emmanuel;Gulati，Ashutosh;Drew，David
通讯作者：
Drew，David
影响因子：
64.8
作者：
Kim, Jonathan;Tan, Yong Zi;Mancia, Filippo
通讯作者：
Mancia, Filippo
影响因子：
2.5
作者：
Nji, Emmanuel;Traore, Daouda A. K.;Doyle, Declan A.
通讯作者：
Doyle, Declan A.