Endogenous cannabinoid signaling at inhibitory interneurons.

Endogenous cannabinoid signaling at inhibitory interneurons.
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DOI:
10.1016/j.conb.2013.12.006
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发表时间:
2014-06
影响因子:
5.7
通讯作者:
Castillo PE
Castillo PE
中科院分区:
医学2区
文献类型:
--
作者:
Younts TJ;Castillo PE

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Significant progress has been made in our understanding of how endogenous cannabinoids (eCBs) signal at excitatory and inhibitory synapses in the central nervous system (CNS). This review discusses how eCBs regulate inhibitory interneurons, their synapses, and the networks in which they are embedded. eCB signaling plays a pivotal role in brain physiology by means of their synaptic signal transduction, spatiotemporal signaling profile, routing of information through inhibitory microcircuits, and experience-dependent plasticity. Understanding the normal processes underlying eCB signaling is beginning to shed light on how their dysregulation contributes to disease.
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