Static magnetic field enhances the anticancer efficacy of capsaicin on HepG2 cells via capsaicin receptor TRPV1.
Static magnetic field enhances the anticancer efficacy of capsaicin on HepG2 cells via capsaicin receptor TRPV1.
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DOI：
10.1371/journal.pone.0191078
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Chao CY
中科院分区：
文献类型：
--
作者：
Chen WT;Lin GB;Lin SH;Lu CH;Hsieh CH;Ma BL;Chao CY
静磁场（SMF）已显示出一些癌症治疗的可能性。特别是近年来，SMF与抗癌药物的联合作用引起了科学家的关注。然而，药物特异性协同效应的潜在机制远未被理解。此外，使用的药物都是传统的化疗药物，可能会产生令人不快的副作用。在这项研究中，我们的研究结果首次证明，SMF可以增强天然化合物，辣椒素，对HepG2癌细胞的抗癌作用，通过细胞凋亡途径。我们发现，这种协同效应可能是由于SMF增加了辣椒素对TRPV 1通道的结合效率。这些发现可能为开发SMF在癌症治疗中的应用提供支持。本研究首次将SMF与天然化合物结合用于抗癌治疗，为SMF与抗癌药物之间的相互作用提供了额外的见解，并为开发具有最小细胞毒性和副作用的抗癌新策略打开了大门。
Static magnetic field (SMF) has shown some possibilities for cancer therapies. In particular, the combinational effect between SMF and anti-cancer drugs has drawn scientists’ attentions in recent years. However, the underlying mechanism for the drug-specific synergistic effect is far from being understood. Besides, the drugs used are all conventional chemotherapy drugs, which may cause unpleasant side effects. In this study, our results demonstrate for the first time that SMF could enhance the anti-cancer effect of natural compound, capsaicin, on HepG2 cancer cells through the mitochondria-dependent apoptosis pathway. We found that the synergistic effect could be due to that SMF increased the binding efficiency of capsaicin for the TRPV1 channel. These findings may provide a support to develop an application of SMF for cancer therapy. The present study offers the first trial in combining SMF with natural compound on anti-cancer treatment, which provides additional insight into the interaction between SMF and anti-cancer drugs and opens the door for the development of new strategies in fighting cancer with minimum cytotoxicity and side effects.
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影响因子：
7.2
作者：
Fang, Evandro Fei;Zhang, Chris Zhi Yi;Tzi Bun Ng
通讯作者：
Tzi Bun Ng
影响因子：
2.7
作者：
Del Seppia, C;Mezzasalma, L;Ghione, S
通讯作者：
Ghione, S
DOI：
10.1073/pnas.94.8.3668
发表时间：
1997-04-15
影响因子：
11.1
作者：
Hsu, YT;Wolter, KG;Youle, RJ
通讯作者：
Youle, RJ
影响因子：
4.7
作者：
Amantini, C.;Mosca, M.;Santoni, G.
通讯作者：
Santoni, G.
DOI：
10.1124/jpet.106.116657
发表时间：
2007-06-01
影响因子：
3.5
作者：
Gunthorpe, Martin J.;Hannan, Sara Luis;Davis, John B.
通讯作者：
Davis, John B.