The feasibility and safety of a simple method for coronary sinus blood sampling during catheter ablation of arrhythmias.
The feasibility and safety of a simple method for coronary sinus blood sampling during catheter ablation of arrhythmias.
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心律失常导管消融术中简单冠状窦采血方法的可行性和安全性
DOI：
10.21037/atm-21-6973
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发表时间：
2022-03
影响因子：
--
通讯作者：
Li S
中科院分区：
文献类型：
--
作者：
Zheng Z;Wu B;Chen Q;Luo Y;Tang X;Wang J;Xie X;Dong R;Li W;Zhu J;Li S
背景冠状静脉窦（CS）血液采样可以深入了解心脏病的局部病理生理学。然而，在大多数以前的研究中，需要额外的专门设计或修改的导管，使得临床应用的便利性不令人满意。本研究旨在介绍一种在心律失常的导管消融（CA）过程中无需使用额外导管的简单CS采血方法，并探讨其可行性和安全性。方法前瞻性研究119例CA患者，其中阵发性室上性心动过速（PSVT）25例，室性早搏（PVC）30例，心房颤动（AF）64例。在6 F可控诊断导管（St. Jude Medical）引导下，使用传统的8 F SR 0 TM或8.5F SL 1 TM导引鞘（St. Jude Medical）经股静脉进行CS插管和采样。记录成功率和任何可疑并发症。还对CS样品与外周静脉样品进行了基于非靶向液相色谱-质谱（LC-MS）的代谢组学研究。结果114例患者成功采集CS血样，总成功率为95.8%。在不同心律失常患者中，成功率相似，PSVT为96.0%，PVC为96.7%，AF为95.3%（P=0.223）。4例（3.4%）患者发生不良事件，包括2例偶发性房性异位搏动，但未引起任何不适，2例新发阵发性AF持续约2 min，未发现严重并发症。代谢组学分析显示，与外周血样本相比，CS样本提供了许多不同的代谢物（PVST中93种，PVC中217种，AF中109种）。结论我们的方法用于CA期间CS采血是可行的和安全的，并且可以提供与外周样品显著不同的有用的心脏代谢信息。
Background Coronary sinus (CS) blood sampling gives an insight into the localized pathophysiology of heart diseases. However, additional specifically-designed or modified catheters were needed in most previous studies, making the convenience of clinical application unsatisfactory. This study aimed to introduce a simple method for CS blood sampling without using additional catheters during catheter ablation (CA) of arrhythmias, and to investigate its feasibility and safety. Methods A total of 119 patients undergoing CA were prospectively enrolled, including 25 with paroxysmal supraventricular tachycardia (PSVT), 30 with premature ventricular complexes (PVC), and 64 with atrial fibrillation (AF). Cannulation and sampling of CS was performed via the femoral vein using a conventional 8F SR0TM or 8.5F SL1TM introducer sheath (St. Jude Medical) guided by a 6F steerable diagnostic catheter (St. Jude Medical). The success rate and any suspicious complications were recorded. Untargeted liquid chromatograph-mass spectrometer (LC-MS)-based metabonomics of CS samples versus peripheral venous samples were also performed. Results CS blood samples were successfully collected from 114 patients, with an overall success rate of 95.8%. Among patients with different arrhythmias, the success rates were similar, with 96.0% in PSVT, 96.7% in PVC, and 95.3% in AF (P=0.223). Adverse events occurred in four (3.4%) patients, including two patients with occasional atrial ectopic beats without causing any discomfort, and two patients with new-onset paroxysmal AF lasting for about 2 min. No serious complications were noted. Metabonomics analysis showed that CS samples provided a number of different metabolites (93 in PVST, 217 in PVC, and 109 in AF) versus peripheral samples. Conclusions Our method for CS blood sampling during CA is feasible and safe, and can provide useful cardiometabolic information that is significantly different from a peripheral sample.
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DOI：
10.1136/heartjnl-2016-310789
发表时间：
2017-08
期刊：
Heart (British Cardiac Society)
影响因子：
--
作者：
Ward-Caviness CK;Xu T;Aspelund T;Thorand B;Montrone C;Meisinger C;Dunger-Kaltenbach I;Zierer A;Yu Z;Helgadottir IR;Harris TB;Launer LJ;Ganna A;Lind L;Eiriksdottir G;Waldenberger M;Prehn C;Suhre K;Illig T;Adamski J;Ruepp A;Koenig W;Gudnason V;Emilsson V;Wang-Sattler R;Peters A
通讯作者：
Peters A
影响因子：
37.8
作者：
Maier, W;Altwegg, LA;Lüscher, TF
通讯作者：
Lüscher, TF
DOI：
10.1038/nrm.2016.25
发表时间：
2016-07
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Johnson CH;Ivanisevic J;Siuzdak G
通讯作者：
Siuzdak G
影响因子：
24
作者：
Ajijola, Olujimi A.;Chatterjee, Neal A.;Herring, Neil
通讯作者：
Herring, Neil
DOI：
10.1002/ccd.1810120616
发表时间：
1986-01-01
期刊：
CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS
影响因子：
--
作者：
DEHMER, GJ;SCHMITZ, JM;MALLOY, CR
通讯作者：
MALLOY, CR