Rapid neocortical dynamics: cellular and network mechanisms.

Rapid neocortical dynamics: cellular and network mechanisms.
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DOI:
10.1016/j.neuron.2009.04.008
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发表时间:
2009-04-30
期刊:
影响因子:
16.2
通讯作者:
McCormick, David A.
McCormick, David A.
中科院分区:
医学1区
文献类型:
--
作者:
Haider, Bilal;McCormick, David A.

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新皮质脑片的高度互联的局部和大规模网络根据行为需求快速、动态地调节其功能连接。新皮质的这一基本工作原理是由兴奋性和抑制性突触屏障的持续变化所介导的,这些突触屏障不仅控制神经元在网络中的参与,而且还定义网络本身。通过突触轰击快速控制神经元的反应性是皮层动力学的一个基本特性,它可能为包括感觉知觉、运动整合、工作记忆和注意在内的各种行为提供基础。
The highly interconnected local and large-scale networks of the neocortical sheet rapidly and dynamically modulate their functional connectivity according to behavioral demands. This basic operating principle of the neocortex is mediated by the continuously changing flow of excitatory and inhibitory synaptic barrages that not only control participation of neurons in networks but also define the networks themselves. The rapid control of neuronal responsiveness via synaptic bombardment is a fundamental property of cortical dynamics that may provide the basis of diverse behaviors, including sensory perception, motor integration, working memory, and attention.
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