Transcranial static magnetic stimulation over the motor cortex can facilitate the contralateral cortical excitability in human.
Transcranial static magnetic stimulation over the motor cortex can facilitate the contralateral cortical excitability in human.
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DOI：
10.1038/s41598-021-84823-4
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发表时间：
2021-03-08
影响因子：
4.6
通讯作者：
Mima T
中科院分区：
文献类型：
--
作者：
Takamatsu Y;Koganemaru S;Watanabe T;Shibata S;Yukawa Y;Minakuchi M;Shimomura R;Mima T
经颅静态磁刺激（transcranial static magnetic stimulation，tSMS）作为一种新型的无创性脑刺激技术，能够抑制磁体下方大脑皮层的兴奋性，已成为近年来的研究热点。然而，迄今为止，关于tSMS通过脑网络的非区域效应的研究很少。我们研究了是否tSMS在左侧初级运动皮层（M1）可以促进右侧M1在健康受试者，基于以下假设，即M1的功能抑制可以通过减少双侧M1之间的纵裂抑制（IHI）引起对侧M1的矛盾功能促进。本研究为双盲交叉试验。我们测量了皮质脊髓兴奋性在M1和IHI从左到右M1通过记录运动诱发电位从第一背侧骨间肌使用单脉冲和成对脉冲经颅磁刺激之前和之后的tSMS干预30分钟。我们发现tSMS后左侧M1的皮质脊髓兴奋性降低，而右侧M1的皮质脊髓兴奋性增加。此外，IHI的评估显示，从左侧到右侧M1的抑制作用减弱。我们的研究结果提供了新的见解的机制理解的神经调节作用的tSMS在人类。
Transcranial static magnetic stimulation (tSMS) has been focused as a new non-invasive brain stimulation, which can suppress the human cortical excitability just below the magnet. However, the non-regional effects of tSMS via brain network have been rarely studied so far. We investigated whether tSMS over the left primary motor cortex (M1) can facilitate the right M1 in healthy subjects, based on the hypothesis that the functional suppression of M1 can cause the paradoxical functional facilitation of the contralateral M1 via the reduction of interhemispheric inhibition (IHI) between the bilateral M1. This study was double-blind crossover trial. We measured the corticospinal excitability in both M1 and IHI from the left to right M1 by recording motor evoked potentials from first dorsal interosseous muscles using single-pulse and paired-pulse transcranial magnetic stimulation before and after the tSMS intervention for 30 min. We found that the corticospinal excitability of the left M1 decreased, while that of the right M1 increased after tSMS. Moreover, the evaluation of IHI revealed the reduced inhibition from the left to the right M1. Our findings provide new insights on the mechanistic understanding of neuromodulatory effects of tSMS in human.
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影响因子：
5.3
作者：
Gonzalez-Rosa, Javier J.;Soto-Leon, Vanesa;Oliviero, Antonio
通讯作者：
Oliviero, Antonio
影响因子：
5.5
作者：
Gerloff, C;Cohen, LG;Hallett, M
通讯作者：
Hallett, M
影响因子：
2.5
作者：
Chen, R;Yung, D;Li, JY
通讯作者：
Li, JY
影响因子：
14.5
作者：
Koganemaru, Satoko;Mima, Tatsuya;Domen, Kazuhisa
通讯作者：
Domen, Kazuhisa
DOI：
10.1016/j.clinph.2012.01.010
发表时间：
2012-05
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Groppa S;Oliviero A;Eisen A;Quartarone A;Cohen LG;Mall V;Kaelin-Lang A;Mima T;Rossi S;Thickbroom GW;Rossini PM;Ziemann U;Valls-Solé J;Siebner HR
通讯作者：
Siebner HR