Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine.
Plasticity of differentiated cells in wound repair and tumorigenesis, part II: skin and intestine.
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DOI：
10.1242/dmm.035071
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发表时间：
2018-08-31
影响因子：
4.3
通讯作者：
Mills JC
中科院分区：
文献类型：
--
作者：
Burclaff J;Mills JC
最近的研究已经确定并开始描述再生细胞可塑性在许多器官中的作用。在我们的两部分综述的第一部分中，我们讨论了胃和胰腺损伤后细胞如何重新编程。我们引入了保守细胞程序的概念，就像那些控制分裂和死亡的程序一样，这可能允许成熟细胞再生。这个程序，paligenosis，可能是必要的，以帮助器官修复他们在生物体的一生中面临的许多损伤;然而，我们也假设，paligenosis和再分化的轮次可能允许长寿细胞积累和储存致癌突变，从而可能有助于肿瘤的发生。我们将这种模型称为肿瘤发生的“周期性打击”模型，其中分化的细胞可以储存突变，然后在细胞周期重新进入时揭开它们。在本综述（第二部分）中，我们讨论了这些概念，以及皮肤和肠道中的细胞可塑性。虽然皮肤和肠的分化和修复可以说比胃和胰腺更彻底地研究，但成熟的皮肤和肠细胞如何促进肿瘤发生尚不清楚。此外，我们通过讨论所有四个器官中的可塑性来结束我们的综述，并寻找保守的机制和概念，这些机制和概念可能有助于提高我们对肿瘤形成的认识，并促进治疗或预防可能在多个器官中共享的癌症的疗法的发展。总结：这是两部分综述的最后一部分，讨论了去分化和再分化的周期如何促进皮肤和肠道的肿瘤发生，显示了这些不断更新的组织中的可塑性如何有助于肿瘤发生。
Recent studies have identified and begun to characterize the roles of regenerative cellular plasticity in many organs. In Part I of our two-part Review, we discussed how cells reprogram following injury to the stomach and pancreas. We introduced the concept of a conserved cellular program, much like those governing division and death, which may allow mature cells to become regenerative. This program, paligenosis, is likely necessary to help organs repair the numerous injuries they face over the lifetime of an organism; however, we also postulated that rounds of paligenosis and redifferentiation may allow long-lived cells to accumulate and store oncogenic mutations, and could thereby contribute to tumorigenesis. We have termed the model wherein differentiated cells can store mutations and then unmask them upon cell cycle re-entry the ‘cyclical hit’ model of tumorigenesis. In the present Review (Part II), we discuss these concepts, and cell plasticity as a whole, in the skin and intestine. Although differentiation and repair are arguably more thoroughly studied in skin and intestine than in stomach and pancreas, it is less clear how mature skin and intestinal cells contribute to tumorigenesis. Moreover, we conclude our Review by discussing plasticity in all four organs, and look for conserved mechanisms and concepts that might help advance our knowledge of tumor formation and advance the development of therapies for treating or preventing cancers that might be shared across multiple organs. Summary: This final installment of a two-part Review discusses how cycles of dedifferentiation and redifferentiation can promote tumorigenesis in the skin and intestine, showing how plasticity in these continuously renewing tissues might contribute to tumorigenesis.
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影响因子：
23.9
作者：
Brownell, Isaac;Guevara, Elizabeth;Bai, C. Brian;Loomis, Cynthia A.;Joyner, Alexandra L.
通讯作者：
Joyner, Alexandra L.
影响因子：
64.8
作者：
Buczacki, Simon J. A.;Zecchini, Heather Ireland;Winton, Douglas J.
通讯作者：
Winton, Douglas J.
影响因子：
64.5
作者：
BAILLEUL, B;SURANI, MA;BALMAIN, A
通讯作者：
BALMAIN, A
影响因子：
21.3
作者：
Donati G;Rognoni E;Hiratsuka T;Liakath-Ali K;Hoste E;Kar G;Kayikci M;Russell R;Kretzschmar K;Mulder KW;Teichmann SA;Watt FM
通讯作者：
Watt FM
影响因子：
29.4
作者：
Collins MA;Yan W;Sebolt-Leopold JS;Pasca di Magliano M
通讯作者：
Pasca di Magliano M