Wounding induces dedifferentiation of epidermal Gata6(+) cells and acquisition of stem cell properties.
Wounding induces dedifferentiation of epidermal Gata6(+) cells and acquisition of stem cell properties.
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DOI：
10.1038/ncb3532
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发表时间：
2017-06
影响因子：
21.3
通讯作者：
Watt FM
中科院分区：
文献类型：
--
作者：
Donati G;Rognoni E;Hiratsuka T;Liakath-Ali K;Hoste E;Kar G;Kayikci M;Russell R;Kretzschmar K;Mulder KW;Teichmann SA;Watt FM
表皮由多个干细胞群体维持，这些干细胞群体的后代沿着不同的、空间上不同的谱系分化。在这里，我们证明了转录因子GATA6控制着先前未描述的皮脂腺导管(SD)谱系的身份，并鉴定了GATA6下游转录因子网络，该网络指定了皮脂细胞和SD细胞之间的谱系转换。在伤口愈合过程中，分化的GATA6+细胞从SD迁移到毛囊间表皮并去分化，获得了长期自我更新的能力，并分化为比未损伤组织更广泛的表皮谱系。我们的数据不仅表明连接区的结构和功能的复杂性受到GATA6的调节，而且还揭示了去分化是先前未被认识到的与基底膜失去联系的有丝分裂后终末分化细胞的特性。这解决了关于终末分化细胞在表皮伤口修复中的作用的长期争论。
The epidermis is maintained by multiple stem cell populations whose progeny differentiate along diverse, and spatially distinct, lineages. Here we show that the transcription factor Gata6 controls the identity of the previously uncharacterized sebaceous duct (SD) lineage and identify the Gata6 down-stream transcription factor network that specifies a lineage switch between sebocytes and SD cells. During wound healing differentiated Gata6+ cells migrate from the SD into the interfollicular epidermis and dedifferentiate, acquiring the ability to undergo long-term self-renewal and differentiate into a much wider range of epidermal lineages than in undamaged tissue. Our data not only demonstrate that the structural and functional complexity of the junctional zone is regulated by Gata6, but also reveal that dedifferentiation is a previously unrecognized property of post-mitotic, terminally differentiated cells that have lost contact with the basement membrane. This resolves the long-standing debate about the contribution of terminally differentiated cells to epidermal wound repair.
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影响因子：
64.5
作者：
Fujiwara H;Ferreira M;Donati G;Marciano DK;Linton JM;Sato Y;Hartner A;Sekiguchi K;Reichardt LF;Watt FM
通讯作者：
Watt FM
影响因子：
64.8
作者：
Buczacki, Simon J. A.;Zecchini, Heather Ireland;Winton, Douglas J.
通讯作者：
Winton, Douglas J.
DOI：
10.1126/science.1242281
发表时间：
2014-06-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Blanpain C;Fuchs E
通讯作者：
Fuchs E
影响因子：
64.5
作者：
Hsu YC;Pasolli HA;Fuchs E
通讯作者：
Fuchs E
影响因子：
16
作者：
Heinz S;Benner C;Spann N;Bertolino E;Lin YC;Laslo P;Cheng JX;Murre C;Singh H;Glass CK
通讯作者：
Glass CK