Promotive effects of four herbal medicine ARCC on wound healing in mice and human.
Promotive effects of four herbal medicine ARCC on wound healing in mice and human.
复制标题
四种草药 ARCC 对小鼠和人类伤口愈合的促进作用
DOI：
10.1002/hsr2.494
复制
发表时间：
2022-05
影响因子：
2
通讯作者：
Fu, Xiaobing
中科院分区：
文献类型：
--
作者：
Zhong, Lingzhi;Shi, Cuijuan;Hou, Qian;Yang, Rungong;Li, Meirong;Fu, Xiaobing
中药在中国已被广泛用于伤口治疗，并在伤口治疗中显示出巨大的潜力，但其机制仍需进一步研究。本研究旨在探讨中医 ARCC 对急慢性伤口的治疗效果。这里，采用超低温制备方法，将当归（A）、当归（R）、熟石膏（C）和卡莱酰胺（C）混合超微粉末命名为ARCC。通过全层皮肤缺损模型比较评估 ARCC 对成年和老年小鼠伤口愈合的影响。此外，我们从 500 名糖尿病足患者中随机选取 10 名年龄在 55 至 70 岁之间的患者来评估他们的预后。结果表明，与成年小鼠相比，老年小鼠的愈合速度有所延迟，而 ARCC 显着增强了老年小鼠的愈合过程。此外，老年小鼠的 ARCC 治疗伤口表现出上皮再生加速、肉芽组织形成增强和血管化增加，这与成年小鼠相似。此外，ARCC还对糖尿病足患者取得了治疗效果，加速了伤口愈合。结果发现，给予 ARCC 后 7 天，足部溃疡明显改善，80% 的患者在 1 个月内痊愈。在本研究中，发现 ARCC 对动物模型的急性和慢性伤口均具有治疗作用。 ARCC 还展示了对糖尿病足的治疗效果，可促进伤口愈合、预防伤口感染，并避免进一步手术或截肢的风险。所有这些证据表明 ARCC 是一种有前途的伤口治疗方法。 ARCC 可能被推荐作为糖尿病和慢性难治性伤口的一种有前景的治疗药物。
Traditional Chinese medicine (TCM) had been extensively used in China for wound management and had shown great potential in wound treatment while its mechanism is still needed to be addressed. The present study sought to investigate the therapuetic effect of the TCM ARCC on acute and chronic wounds. Here, using the ultra‐low temperature preparation method, the mixed ultramicro powder prepared with Angelica (A), Angelica (R), Calcined Gypsum (C) and Caleramide (C) named as ARCC. The effects of ARCC on wound healing in adult and aged mice were comparatively evaluated through a full‐thickness skin defect model. In addition, we randomly selected 10 patients aged 55 to 70 years from a cohort of 500 patients with diabetic feet to assess their prognosis. As the results showed that the healing rate had delayed in aged mice compared to adult mice, while ARCC prominently augmented the healing process in aged mice. Moreover, ARCC treatment wounds in aged mice showed accelerated re‐epithelization, enhanced granulation tissue formation, and increased vascularization, which was similar to that of adult mice. Furthermore, ARCC also achieved therapeutic effects in diabetic foot patients, accelerating wound healing. The results found that foot ulcers improved significantly 7 days after the ARCC administration, and 80% of patients were healed within 1 month. In the present study, ARCC was found to have therapeutic effects on both acute and chronic wounds in animal models. ARCC also demonstrated therapeutic effects in diabetic feet, which promoted wound healing, prevented wound infection, and avoided the risk of further surgery or amputation. All these evidences suggested ARCC was a promising approach for wound treatment. ARCC might be recommended as a promising therapeutic medication in diabetic and chronic refractory wounds.
DOI：
10.3988/jcn.2005.1.2.121
发表时间：
2005-10
期刊：
Journal of clinical neurology (Seoul, Korea)
影响因子：
--
作者：
Koh JY
通讯作者：
Koh JY