Effects of androgenic properties of progestin combined with ethinyl estradiol on vascular endothelial reactivity, plasma lipids and free radical production in women with endometriosis
Effects of androgenic properties of progestin combined with ethinyl estradiol on vascular endothelial reactivity, plasma lipids and free radical production in women with endometriosis
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孕激素联合乙炔雌二醇的雄激素特性对子宫内膜异位症女性血管内皮反应性、血脂和自由基产生的影响
DOI：
10.1111/jog.14620
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发表时间：
2021
影响因子：
1.6
通讯作者：
Wakatsuki Akihiko
中科院分区：
文献类型：
--
作者：
Sakurada Takahiro;Matsushita Hiroshi;Noguchi Yasuyuki;Shinohara Koichi;Watanabe Kazushi;Wakatsuki Akihiko
目的子宫内膜异位症患者内皮细胞反应性受到抑制，氧化应激增强。替吉奥可能对脂质和内皮细胞产生不良影响。我们研究了雄激素性质的孕激素结合炔雌醇（EE）对内皮功能，脂质和自由基的生产在这样的women.MethodsWomen子宫内膜异位症治疗与20 μg EE + 3 mg屈螺酮（DRSP）或35 μg EE + 1 mg炔诺酮（NET）3个月。在治疗前后测量性激素结合球蛋白（SHBG）、脂质、铜（Cu）、活性氧代谢产物衍生物（d-ROM）、生物抗氧化潜力（BAP）、亚硝酸盐/硝酸盐、内皮素-1和不对称二甲基精氨酸（ADMA）的血浆浓度。血流介导的血管舒张（FMD）的肱动脉测量通过ultrasonography.ResultsDRSP组，但不是NET组，显着增加FMD和浓度的亚硝酸盐/硝酸盐和小密度低密度脂蛋白胆固醇，而降低内皮素-1浓度。在两组中，ADMA和LDL胆固醇浓度显著降低，但甘油三酯、SHBG、d-ROM、Cu和铜蓝蛋白浓度升高，BAP浓度没有变化。DRSP组显著升高HDL胆固醇浓度，而NET组降低其浓度。甘油三酯的变化与SHBG的变化（r= 0.57，P < 0.001）或与小而密LDL胆固醇的变化（r= 0.45，P = 0.005）呈正相关。结论灯盏花素的促雄激素作用可能抵消雌激素对子宫内膜异位症患者内皮功能和HDL胆固醇的有利影响，同时消除其对甘油三酯引起的小密度LDL胆固醇升高的不利影响。
AimEndothelial reactivity is inhibited and oxidative stress is enhanced in women with endometriosis. Testosterone may adversely affect lipids and endothelium. We investigated the effects of androgenic properties of progestins combined with ethinyl estradiol (EE) on endothelial function, lipids and free radical production in such women.MethodsWomen with endometriosis were treated with 20 μg EE + 3 mg drospirenone (DRSP) or 35 μg EE + 1 mg norethisterone (NET) for 3 months. Plasma concentrations of sex hormone‐binding globulin (SHBG), lipids, copper (Cu), derivatives of reactive oxygen metabolites (d‐ROMs), biological antioxidant potential (BAP), nitrite/nitrate, endothelin‐1 and asymmetrical dimethylarginine (ADMA) were measured before and after treatment. Flow‐mediated vasodilation (FMD) of the brachial artery was measured by ultrasonography.ResultsDRSP group, but not NET group, significantly increased FMD and concentrations of nitrite/nitrate and small dense LDL cholesterol, while decreased endothelin‐1 concentrations. In both groups, ADMA and LDL cholesterol concentrations were significantly decreased, but triglyceride, SHBG, d‐ROMs, Cu and ceruloplasmin concentrations increased, and BAP concentrations did not change. DRSP group significantly increased HDL cholesterol concentrations, whereas NET group decreased its concentrations. Changes in triglyceride correlated positively either with changes in SHBG (r= 0.57,P< 0.001) or with small dense LDL cholesterol (r= 0.45,P= 0.005). Changes in Cu correlated positively with changes in d‐ROMs (r= 0.87,P< 0.001).ConclusionAndrogenic properties of progestin may counteract EE's favorable effects on endothelial function and HDL cholesterol, while eliminating its adverse effects on increased triglyceride‐induced small dense LDL cholesterol in women with endometriosis.
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监测氧化应激的简单测试。
影响因子：
1.4
作者：
Cesarone Mr;G. Belcaro;M. Carratelli;U. Cornelli;De Sanctis Mt;L. Incandela;Antonio Barsotti;R. Terranova;A. Nicolaides
通讯作者：
A. Nicolaides
DOI：
10.1161/01.cir.0000084552.54277.64
发表时间：
2003-08
期刊：
Circulation: Journal of the American Heart Association
影响因子：
--
作者：
A. Wakatsuki;Y. Okatani;N. Ikenoue;K. Shinohara;Kazushi Watanabe;T. Fukaya
通讯作者：
A. Wakatsuki;Y. Okatani;N. Ikenoue;K. Shinohara;Kazushi Watanabe;T. Fukaya
影响因子：
2.9
作者：
GREEN, LC;WAGNER, DA;TANNENBAUM, SR
通讯作者：
TANNENBAUM, SR
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影响因子：
6.1
作者：
Luca Santoro;F. D’Onofrio;S. Campo;Pietro Manuel Ferraro;P. Tondi;V. Campo;Andrea Flex;A. Gasbarrini;A. Santoliquido
通讯作者：
A. Santoliquido
七种低剂量复方口服避孕药对性激素结合球蛋白、皮质类固醇结合球蛋白、总睾酮和游离睾酮的影响。
影响因子：
2.9
作者：
N. Vange;M. Blankenstein;H. Kloosterboer;A. Haspels;J. Thijssen
通讯作者：
J. Thijssen