Breathprints of childhood obesity: changes in volatile organic compounds in obese children compared with lean controls.
Breathprints of childhood obesity: changes in volatile organic compounds in obese children compared with lean controls.
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DOI：
10.1111/j.2047-6310.2014.221.x
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发表时间：
2015-02
影响因子：
3.8
通讯作者：
Dweik RA
中科院分区：
文献类型：
--
作者：
Alkhouri N;Eng K;Cikach F;Patel N;Yan C;Brindle A;Rome E;Hanouneh I;Grove D;Lopez R;Hazen SL;Dweik RA
这项研究的目的是调查超重/肥胖儿童呼气中挥发性有机化合物(VOCs)的变化，并与他们的瘦儿童进行比较。采用选择性离子流动管质谱(SIFT-MS)采集呼气中的单次呼气并进行分析。研究对象包括60名超重/肥胖儿童和55名瘦身对照儿童。与瘦肉组相比，肥胖组的年龄(14.1±2.8比12.1±3.0岁)，身高(164.8±10.9比153.3±17.1厘米)，更有可能是高加索人(60%比35.2%)。将肥胖组和瘦肉组的SIFT-MS结果进行比较，发现50多种化合物的浓度存在差异。一个由四个VOC组成的小组可以非常准确地识别超重/肥胖的存在。进一步分析发现，肥胖组的呼气异戊二烯、1-癸烯、1-辛烯、氨和硫化氢显著高于瘦肉组(p值均为0.01)。肥胖儿童呼出的VOCs有一种独特的模式。这项研究中观察到的VOCs的变化可能有助于深入了解导致儿童肥胖发展的病理生理过程和途径。
The objective of this study was to investigate changes in volatile organic compounds (VOCs) in exhaled breath in overweight/ obese children compared to their lean counterparts. Single exhaled breath was collected and analyzed per protocol using selective ion flow tube mass spectrometry (SIFT-MS). 60 overweight/ obese children and 55 lean controls were included. Compared to the lean group, the obese group was significantly older (14.1 ± 2.8 vs. 12.1 ± 3.0 years), taller (164.8 ± 10.9 vs. 153.3 ± 17.1 cm), and more likely to be Caucasian (60% vs. 35.2%); p < 0.05 for all. A comparison of the SIFT-MS results of the obese group to the lean group revealed differences in concentration of more than 50 compounds. A panel of four VOCs can identify the presence of overweight/ obesity with excellent accuracy. Further analysis revealed that breath isoprene, 1-decene, 1-octene, ammonia and hydrogen sulfide were significantly higher in the obese group compared to lean group (p value < 0.01 for all). Obese children have a unique pattern of exhaled VOCs. Changes in VOCs observed in this study may help to gain insight into pathophysiological processes and pathways leading to the development of childhood obesity.
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影响因子：
2
作者：
Prince, Barry J.;Milligan, Daniel B.;McEwan, Murray J.
通讯作者：
McEwan, Murray J.
影响因子：
25.7
作者：
Simonen, Piia;Kotronen, Anna;Yki-Jarvinen, Hannele
通讯作者：
Yki-Jarvinen, Hannele
影响因子：
168.9
作者：
Phillips, M;Gleeson, K;McVay, WP
通讯作者：
McVay, WP
DOI：
10.1097/jto.0b013e3182637d5f
发表时间：
2012-10
期刊：
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子：
--
作者：
Peled N;Hakim M;Bunn PA Jr;Miller YE;Kennedy TC;Mattei J;Mitchell JD;Hirsch FR;Haick H
通讯作者：
Haick H
影响因子：
120.7
作者：
Ogden, Cynthia L.;Carroll, Margaret D.;Flegal, Katherine M.
通讯作者：
Flegal, Katherine M.